The Effectiveness of Daily Protein Supplementation With a Plant Protein Blend or Milk Protein to Support Integrated Muscle Protein Synthesis Rates With and Without Exercise in Healthy Older Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- Integrated muscle protein synthesis rates in the non-exercised leg.
研究概览
简要总结
Background Protein intake is important for skeletal muscle mass maintenance with aging and the ingestion of specifically-timed protein supplements could increase overall protein intake and thereby contribute to skeletal muscle mass maintenance. Recently, more attention has been given to the ingestion of plant-based protein blends as a more sustainable high-quality alternative to milk protein, as a means to increase muscle protein build-up and, as such, support muscle maintenance, especially when consuming suboptimal amounts of protein in the regular diet.
Objective To assess the benefit of daily protein supplementation with either a plant-based protein blend or a milk protein on top of a standard diet to stimulate integrated muscle protein synthesis rates in healthy older individuals with and without exercise.
Hypotheses It is hypothesized that both the plant protein blend and the milk protein supplement will result in greater muscle protein build-up when compared with a standard diet control condition.
It is also hypothesized that exercise will result in greater muscle protein build-up when compared to the resting leg in all conditions, with similar effects of the protein supplements vs the control diet as in the non-exercised leg.
This study will show the potential benefit of protein supplementation with alternative protein sources to support skeletal muscle maintenance in older individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Protein supplements are packed the same and look and taste similar.
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female sex
- •Aged between 60 and 80 y inclusive
- •BMI between 18.5 and 30 kg/m2
排除标准
- •Following a self-reported vegetarian and vegan diet the 6 months prior to the study.
- •Intolerant to milk products
- •Corn allergy
- •Pea allergy
- •Participating currently or in the 3 months prior to the study in a structured (progressive) exercise program.
- •Smoking regularly (i.e. >5 cigarettes/week)
- •History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the principal investigator and responsible physician)
- •Diagnosed with phenylketonuria (PKU)
- •Uncontrolled hypertension (blood pressure above 160/100 mmHg)
- •Donated blood 3 months prior to test day
- •Use of any medications that interferes with study participation and/or outcomes (i.e. corticosteroids, non-steroidal anti-inflammatories, gastric acid suppressing medication) as assessed by the responsible medical doctor.
- •Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants
- •Pregnancy
结局指标
主要结局
Integrated muscle protein synthesis rates in the non-exercised leg.
时间窗: 10 days
Calculated by the changein deuterium labelled alanine in skeletal muscle protein
次要结局
- Dietary fat intake(10 days)
- Step count(10 days)
- Dietary protein intake(10 days)
- Integrated muscle protein synthesis rates in the exercised leg.(10 days)
- Muscle Crosssectional are(10 days)
- Dietary carbohydrate intake(10 days)