ISRCTN65344386已完成未知
Feasibility of the Safe Withdrawal of inhaled corticosteroids in Patients with mild to moderate COPD prescribed outside guidelines
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 106
研究概览
简要总结
2019 preliminary research in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978678/ (added 17/06/2020) 2019 qualitative results in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566471/ (added 17/06/2020)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Known diagnosis of mild or moderate COPD (forced expiratory volume in first second (FEV1) =50% predicted and FEV1/forced vital capacity (FVC) <0.7) obtained from spirometry within the past 12 months and confirmed at interview
- •2. Prescribed and have used high-dose ICS (alone or in combination with a long-acting bronchodilator) at a dose of fluticasone propionate =250mcg/day, fluticasone furoate =92mcg/day, budesonide >400mcg/day or beclomethasone dipropionate >400mcg/day on most days for at least 3 months
- •3. Age = 45 years
- •4. <2 exacerbations in the previous year and no admissions to hospital with an exacerbation since the diagnosis of COPD was made
- •5. BMI of less than 35
排除标准
- •1. Patients with a BMI greater than 35
- •2. History of asthma
- •3. Lung cancer
- •4. Breathlessness secondary to cardiac disease
- •5. Moderate or severe osteoarthritis limiting mobility
- •6. Current severe mental illness (severe depression or psychosis)
- •7. Current alcohol dependence
- •8. Dementia
- •9. Patients who use continuous oral corticosteroids
- •10. Pregnant females or females of childbearing age not using effective contraception
研究者
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