NCT05656222撤回不适用
A Retrospective Study Investigating the Combination of Irinotecan, Vincristine and Anlotinib for Epithelioid Sarcoma
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Objective Response Rate
研究概览
简要总结
Epithelioid sarcoma is a rare soft tissue sarcoma characterized by SMARCB1/INI1 deficiency. Much attention has been paid to the selective EZH2 inhibitor tazemetostat, where other systemic treatments are generally ignored. To explore alternative treatment options, we studied the effects of irinotecan-based chemotherapy in a series of epithelioid sarcoma patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 3 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1) Grade 2 or 3 ES confirmed histologically using the American Joint Committee on Cancer (AJCC) system ;
- •(2) patients presented with measurable lesions using the Response Evaluation Criteria In Solid Tumors (RECIST1.1) and were not amenable to surgical resection or radiotherapy;
- •(3) primary or secondary metastatic disease;
- •(4) received more than two courses of the VIA regimen;
- •(5) no concurrent treatment was given while on the VIA regimen;
- •(6) follow-up information and evaluation after chemotherapy were available.
排除标准
- •less than 4 cycles of treatment;
- •medical records were not complete.
研究组 & 干预措施
VIA treatment Group
Experimental
干预措施: VIA combination treatment (Drug)
结局指标
主要结局
Objective Response Rate
时间窗: 12 weeks
Based on RECIST1.1 criteria, clinical evaluation was done once every 6 weeks
次要结局
未报告次要终点
研究者
Xie Lu
Musculoskeletal Tumor Center
Peking University People's Hospital
研究点 (1)
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