Serial Multiomics Profiling Using Serum and Cerebrospinal Fluid Samples Following Out-of-hospital Cardiac Arrest: a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Neurological outcome
研究概览
简要总结
The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples. The main question it aims to answer is:
A. The main question it aims to answer is: What are the dynamic molecular changes in serum and CSF that reflect the pathophysiological mechanisms of secondary brain injury after cardiac arrest? B. What are the differences in serum and CSF multiomic signatures between varying severities of cardiac arrest, and how are these differences associated with the underlying pathophysiological mechanisms of secondary brain injury?
Serum and CSF samples that have already been prospectively collected from participants and stored in the BioBank will be used for this analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years old
- •Out-of-hospital cardiac arrest (OHCA)
- •Patients who have received post-resuscitation care including temperature control due to unconsciousness (Glasgow Coma Score < 8) after sustained ROSC.
- •Patients who consented to the placement of lumbar catheter for storing cerebrospinal fluid and blood samples in a human biobank.
排除标准
- •Patients diagnosed with a central nervous system-related disease before cardiac arrest
- •Patients who have undergone extracorporeal circulatory membrane oxygenation therapy
- •Patients who died within 24 hours from post-resuscitation care
研究组 & 干预措施
poor neurologic outcome
Cerebral Performance Category (CPC) : 3 to 5
good neurologic outcome
Cerebral Performance Category (CPC) : 1 or 2
结局指标
主要结局
Neurological outcome
时间窗: after 6 months from return of spontaneous circulation
Neurological outcome is evaluated using the Cerebral Performance Category (CPC) scale. The CPC score ranges from 1 to 5, where 1 indicates good cerebral performance (normal/mild disability), 2 indicates moderate cerebral disability, 3 indicates severe cerebral disability, 4 indicates coma or vegetative state, and 5 indicates brain death. Higher scores represent a worse neurological outcome.
次要结局
- The Pittsburgh Cardiac Arrest Category (PCAC)(immediately after return of spontaneous circulation)
- Illness severity score of cardiac arrest (rCAST)(immediately after return of spontaneous circulation)
研究者
Changshin Kang
Assistant professor
Chungnam National University Hospital