Transient Receptor Potential Channels in Human Skin
试验速览
- 阶段
- 1 期
- 状态
- Enrolling By Invitation
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- Skin blood flow during slow local heating
研究概览
简要总结
Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-85 years old.
- •Women will not be pregnant and/or breastfeeding.
排除标准
- •Currently pregnant or breastfeeding
- •Nicotine use (e.g., smoking, chewing tobacco etc.), quantified as more than 100 cigarettes or cigars in a lifetime)
- •Known skin allergies or current rash, skin disease, disorders of pigmentation
- •Body mass index >35kg*m-2
- •Using calcium channel blockers
- •Raynaud's syndrome
- •Allergy or hypersensitivity to menthol, camphor, capsaicin or adhesive
- •Regular use (defined as greater than once a week) of topical analgesics that contain menthol, camphor or capsaicin
研究组 & 干预措施
Vehicle Gel
Non-active topical gel
干预措施: Vehicle gel (Other)
Transient Receptor Potential (M8) Agonist
Topical menthol gel applied once at 10%
干预措施: TRPM8 Agonist (Drug)
Transient Receptor Potential (V1) Agonist
Topical camphor gel applied once at 0.6%
干预措施: TRPV1 Agonist (Drug)
Transient Receptor Potential (V4) Agonist
Topical capsaicin gel applied once at 0.05%
干预措施: TRPV4 Agonist (Drug)
Transient Receptor Potential M8 V4 V1 Agonist
Topical menthol 10%, capsaicin 0.05%, camphor 0.6% applied once
干预措施: TRPM8, TRPV4, TRPV1 Agonists (Drug)
结局指标
主要结局
Skin blood flow during slow local heating
时间窗: 75 minutes
Laser doppler flowmeter to measure skin blood flow during a slow local heating of the skin
Somatosensory perception
时间窗: every 5 minutes for 120 minues
heat and cold perception using a visual analog scale
algometer measurement
时间窗: every 30 minutes for 120 minutes
pain pressure thresholds
次要结局
未报告次要终点
研究者
Lacy Alexander
Professor of Kinesiology
Penn State University