Assessing the Diagnostic Accuracy of a Three One-minute Tests of Verbal Fluency, Using Artificial Intelligence, in Detecting Mild Cognitive Impairment and Early Dementia.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 221
- 试验地点
- 2
- 主要终点
- Diagnostic performance of Accexible's digital screening battery
研究概览
简要总结
Dementia, especially dementia caused by Alzheimer's disease, is considered one of the most severe health problems of our time. It is currently known that the disease begins many years before clinical symptoms appear. The sooner the patient is diagnosed, the sooner the patient will be in a position to prevent further deterioration.
A recent orientation is the analysis of language in relation to the description of images with a high and varied semantic and emotional content. It can be studied that changes in the description of an image check if these changes are associated with the evolution of a person with probable impairment both in memory and cognitive as well as emotional, psychiatric, behavioral and even in their interaction with environmental factors especially those associated with socialization and loneliness.
The present study has the objective of validating a digital method for detection and follow-up of patients with mild cognitive impairment (MCI) or dementia in a memory clinic setting.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •for patients:
- •Adult patients 55+ years of age with suspected MCI or diagnosis of dementia referred into secondary care memory clinic by their General Practitioner.
- •Have English as first language (able to speak and understand verbal messages).
- •Patients must have agreed to participate in the study and have voluntarily signed the informed consent.
- •Inclusion Criteria for healthy volunteers:
- •Healthy older adults (55+ years of age), without a diagnosis neurological, or psychiatric disorders or any clinical evidence of cognitive decline.
- •Have English as first language (able to speak and understand verbal messages).
- •Controls must have agreed to participate in the study and have voluntarily signed the informed consent.
排除标准
- •for patients:
- •To have received a diagnosis of a significant psychiatric disorder or other cognitive impairment not due to neurodegeneration.
- •To have significant vision problems that would affect the ability to perceive visual stimuli.
- •To have significant hearing problems that would affect the ability to understand verbal cues.
- •To be unable to give informed consent to participate in the study.
- •Exclusion Criteria for healthy volunteers:
- •Objective evidence of significant cognitive decline in any one domain.
- •Score of <88 on ACE-III cognitive testing.
研究组 & 干预措施
Healthy
干预措施: Accexible (Device)
Mild Cognitive Impairment
干预措施: Accexible (Device)
Early Dementia
干预措施: Accexible (Device)
结局指标
主要结局
Diagnostic performance of Accexible's digital screening battery
时间窗: An average of 1 year
Measure the odds that a patient has MCI or dementia measured by vocal biomarkers
次要结局
- Correlation of Accexible's test battery with the ACE III(An average of 1 year)