NCT05976165招募中不适用
Breath Testing for Small Intestinal Bacterial Overgrowth in Patients Treated With Proton Pump Inhibitors
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- Mayo Clinic
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Incidence of SIBO after treatment with PPI
研究概览
简要总结
Researchers hope to determine how often small intestinal bacterial overgrowth occurs after taking proton pump inhibitors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Predominant symptoms of gastroesophageal reflux disease including heartburn, regurgitation
- •Subjects must be able to give appropriate informed consent
排除标准
- •Prior diagnosis of SIBO
- •Use of PPIs or H2R-anatagonstists in the prior 3 months
- •Major concomitant illness (renal, hepatic, rheumatologic or cardiovascular disease, or malignancy)
- •Antibiotic therapy within one month
- •Prior gastrointestinal surgery including esophageal, gastric, and small or large bowel surgery
- •Previously diagnosed irritable bowel syndrome or inflammatory bowel disease
- •Individuals who are pregnant or breast feeding
- •Patients with plans to become pregnant
- •Inability to take PPIs, including allergy/sensitivity
研究组 & 干预措施
Breath Test Evaluation for SIBO
Experimental
Subjects with symptoms of gastroesophageal reflux disease (GERD) treated with a short course of proton pump inhibitors (PPI) clinically will undergo breath testing evaluating for small intestinal bacterial overgrowth (SIBO).
干预措施: Breath Testing (Other)
结局指标
主要结局
Incidence of SIBO after treatment with PPI
时间窗: After PPI therapy, approximately 8 weeks
Number of subjects to have a positive breath testing for small intestinal bacterial overgrowth (SIBO) after clinical treatment of proton pump inhibitors (PPI ).
次要结局
- Symptoms of SIBO after treatment with PPI(After PPI therapy, approximately 8 weeks)
- Symptoms of SIBO before treatment with a PPI(Baseline)
- Incidence of SIBO before treatment with a PPI(Baseline)
研究者
Andree H. Koop
Principal Investigator
Mayo Clinic
研究点 (1)
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