Research on Improving the Intervention Effect of Negative Memory Through tACS Enhanced Memory Technology
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- Negative memory retention
研究概览
简要总结
The objectives of this study include: 1) investigating the impact of negative memory substitution on an individual's other intellectual memories (i.e., neutral memories) and the underlying neurocognitive mechanisms; 2) investigating the memory enhancement effect resulting from retrieval practice associated with memory substitution intervention along with an examination of the neurocognitive mechanisms responsible for this enhancement.
详细描述
This study will adopt two memory updating strategies: retrieval practice and reactivation.
A 5-day memory updating experimental paradigm is used.
- On the first day, the old memory A-B linkage is learned, where A represents a neutral word and B is either neutral or negative pictures (half of each, randomly scrambled).
- On the second day, the old memory A-B association is consolidated again, and after a 15-minute break, the new memory A-C association is learned, where A is still the word A used in the old memory A-B association on the first day, and C is the new neutral and negative pictures (half of each, randomly scrambled, and with inconsistent categories of C and B in each pair of AC and AB). Immediately following this, the new memories of the A-C conjunctions are updated using both Retrieval practice and Restudy (control condition) memory strategies.
- A-C is extracted/learned using both Retrieval practice and Restudy memory strategies on both day 3 and day 4.
- On the fifth day, memory tests for associative memory strength, gist and detail memory, as well as emotional valence and strength are performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 14 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Eligibility
- •Inclusion Criteria:
- •14-60 years old, male or female, Han Chinese;
- •Drug-resistant epilepsy;
- •Required surgical implantation of SEEG electrodes.
排除标准
- •Progressive encephalopathy or progressive structural damage in the central nervous system;
- •Significant heart, liver, renal insufficiency, and other medical diseases;
- •Severe side effects from taking antiepileptic drugs at the time of enrollment and not inappropriate for SEEG;
- •Significant intellectual disability;
- •A history of alcohol and drug abuse;
- •Any contraindication to MRI.
研究组 & 干预措施
Active tACS
Those who participate in the treatment group will receive tACS, which lasts for 40 minutes per day on 3 consecutive days.
干预措施: Active tACS Device (Device)
Sham tACS
Those who participate in the control group will receive sham tACS, which lasts for 40 minutes per day on 3 consecutive days.
干预措施: Sham tACS Device (Device)
结局指标
主要结局
Negative memory retention
时间窗: Day 5
The intervention could disrupt retention of associative negative memory and degree of detail of the negative memories in last A-C paired associate memory test.
次要结局
- The retention of associated neutral memories as assesses by the proportions of responses of correctly choosing picture category of B picture (A-Bneu) in last A-B paired associate memory test(Day 5)
- The negative emotional intensity of neutral memory(Day 5)
- The negative emotional intensity of negative memory(Day 5)