Effects of Creatine Supplementation in Addition to Resistance Exercise Training in Patients With Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Knee Pain: Visual Analogue Scale
研究概览
简要总结
Despite the past decade being dedicated to bone and joint disease, the incidence and prevalence rates of osteoarthritis continues to rise, and till date not curative treatment has been identified for the management of knee osteoarthritis. In terms of conservative management of knee osteoarthritis, pharmacological management has been the mainstay of treatment, however is associated with numerous adverse effects with prolonged use, and it is important to look into the non-pharmacological alternates for the management of knee osteoarthritis. Research has shown resistance exercise training to be the most effective non-pharmacological treatment option for the management of knee osteoarthritis, and the purpose of the current study is to determine if the addition of a non-pharmacological dietry supplement like creatine can amplify the beneficial effects of resistance exercise training in patients with knee osteoarthritis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 40-70 years
- •Knee OA with history not less than three months.
- •Radiological evidences of grade III or less on Kellgren classification.
- •Knee pain on VNRS no more than 8/10
排除标准
- •Neuromuscular conditions that may lead to fatigue such as multiple Sclerosis
- •Signs of serious pathology (e.g., malignancy, inflammatory disorder, infection).
- •History of trauma or fractures in lower extremity.
- •Signs of lumbar radiculopathy or myelopathy.
- •History of knee surgery or replacement.
- •Patients on intra-articular steroid therapy within two months before the commencement of the study.
- •Impaired skin sensation.
- •Impaired renal function
研究组 & 干预措施
Control
干预措施: Home Exercise Plan (Other)
Control
干预措施: Joint Mobilization (Procedure)
Control
干预措施: Lower Extremity Resistance Exercise Training (Other)
Control
干预措施: Electrotherapy + Heating (Device)
Creatine Supplementation
干预措施: Lower Extremity Resistance Exercise Training (Other)
Creatine Supplementation
干预措施: Home Exercise Plan (Other)
Creatine Supplementation
干预措施: Electrotherapy + Heating (Device)
Creatine Supplementation
干预措施: Joint Mobilization (Procedure)
Creatine Supplementation
干预措施: Creatine Supplementation (Dietary Supplement)
结局指标
主要结局
Knee Pain: Visual Analogue Scale
时间窗: 4 weeks
Visual Analogue Scale was used to measure pain scoring from 0-10 cm on a horizontal 10cm line. A greater score reflects higher pain intensity.
Knee Range of Motion
时间窗: 4 weeks
Knee Range of Motion will be quantified by using Gonimeter
Knee Isometric Muscle Strength
时间窗: 4 weeks
Knee Isometric Muscle Strength will be quantified by using Modified Sphygmomanometer Dynamometer
Six Minute Walk Test
时间窗: 4 weeks
Six Minute Walk Test will be used to quantify walking related performance fatigability, walking distance and walking speed.
5 repetition sit to stand test
时间窗: 4 weeks
Time will be measured to perform 5 repetitions of sit to stand activity. Lesser time means a better score.
Knee Pain: Visual Analogue Scale
时间窗: 2 weeks
Visual Analogue Scale was used to measure pain scoring from 0-10 cm on a horizontal 10cm line. A greater score reflects higher pain intensity.
Knee Range of Motion
时间窗: 2 weeks
Knee Range of Motion will be quantified by using Gonimeter
Knee Isometric Muscle Strength
时间窗: 2 weeks
Knee Isometric Muscle Strength will be quantified by using Modified Sphygmomanometer Dynamometer
Six Minute Walk Test
时间窗: 2 weeks
Six Minute Walk Test will be used to quantify walking related performance fatigability, walking distance and walking speed.
5 repetition sit to stand test
时间窗: 2 weeks
Time will be measured to perform 5 repetitions of sit to stand activity. Lesser time means a better score.
次要结局
- Knee Injury and Osteoarthritis Outcome Score (KOOS)(4 weeks)
- Body Composition(4 weeks)
- Fall Risk(4 weeks)
- Knee Injury and Osteoarthritis Outcome Score (KOOS)(2 weeks)
- Body Composition(2 weeks)
- Fall Risk(2 weeks)