Prevalence of Clinical and Laboratory Markers of Hypofibrinolysis in Psychotic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 176
- 试验地点
- 1
- 主要终点
- Prevalence of hypofibrinolysis markers in psychotic patients
研究概览
简要总结
At the Thrombophilia Clinic of the Hospital Federal dos Servidores do Estado do Rio de Janeiro there is a high prevalence of acute psychotic episodes, which allows the investigators to raise the suspicion that the thrombotic tendency or hypofibrinolysis play a role in the onset of the disease. It is striking that most of these patients, after some time on anticoagulants, no longer need to take psychiatric medication.
详细描述
If the thrombotic tendency plays a significant role in the etiology of psychosis, one would expect to find ischemic brain injuries in neuroimaging studies, but it does not happen. Therefore, if there is a correlation between thrombotic tendency-hypofibrinolysis and psychosis it is likely to occur at the biochemical level, such as in neuronal transmission.
The investigators hypothesis is that mechanisms that inhibit tissue plasminogen activator (t-PA) and therefore promote hypofibrinolysis, are directly or indirectly involved in the genesis of psychosis, because t-PA participates in neuronal plasticity and low t-PA levels are related to dementia.
Hypofibrinolysis due to t-PA inhibition can be seen in:
- Insulin resistance, when the pancreas must produce large amounts of insulin and proinsulin by feedback. If pancreatic reserve is inadequate, the result is diabetes mellitus. If the response is adequate, proinsulin stimulates the production of PAI-1 (plasminogen activator inhibitor 1. PAI-1 inhibits the formation of plasmin, whose function is to dissolve fibrin which makes up the clot. Obesity, certain infections and inflammations potentiate insulin resistance.
- Antiphospholipid antibody syndrome.
- PAI-1 4G/5G or 4G/4G polymorphism.
Some hypofibrinolysis indicators are:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of schizophrenia or schizoaffective disorder by the Semi-structured Interview MINI 5.0.
排除标准
- •Inability to provide information.
- •Use of illicit drugs.
- •Infections such as cerebral toxoplasmosis in HIV seropositive or tertiary syphilis. Patients with "recurrent syphilis" will not be excluded, because false positive tests are common in antiphospholipid antibody syndrome.
结局指标
主要结局
Prevalence of hypofibrinolysis markers in psychotic patients
时间窗: One year
The investigators' hypothesis is that a high prevalence of hypofibrinolysis markers will be probably found in psychotic patients.
次要结局
- Prevalence of Clinical and Laboratory Markers of Hypofibrinolysis in Patients who Need Electroconvulsive Therapy(2013-2014)
研究者
Silvia Hoirisch Clapauch
MD, Responsible for the HFSE Thrombophilia Clinic
Universidade Federal do Rio de Janeiro