Colonoscopy in liver transplants (LT): prevalence and risk of advanced adenomas post-LT - Prevalence advanced adenomas post-LT

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 350 人开始时间: 待定最近更新: 2024年5月6日

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•Group A: Post liver transplant patients without pre-LT colonoscopy
•Patients who
•- Have a follow-up of at least 5 years after receiving their first LT.
•- Have had orthotopic liver transplantation (OLT).
•- Have had non-PSC transplant indications;Group B
•B1 Post liver transplant patients with pre-LT colonoscopy negative findings:
•Patients who
•- Have a follow-up of at least 5 years after receiving their first LTx
•- Have had orthotopic liver transplantation (OLT)
•- Are Non-PSC transplant indications
•Colonoscopy results within 5 years of post-LT follow-up in post-LTx patients will also be included in the analyses
•Patients with a post-LTx colonoscopy before 5 years of post-LTx follow-up who are still alive at time at inception, will also be asked to participate in the post liver transplant colonoscopy program (>= 5 year FU)
•B2 Post liver transplant patients with pre-LTx colonoscopy positive findings:
•Patients who
•- Have a follow-up of at least 5 years post-LT
•- Have had orthotopic liver transplantation (OLT)
•- Have had non-PSC transplant indications
•If patients have 3 or more adenomas at pre-LT colonoscopy (which require intensified surveillance work-up in the Dutch polypectomy guideline10), the follow-up colonoscopy results within 3 years of follow-up after the index colonoscopy in post-LTx patients will be included in the analyses. If patients did not receive their appropriate 3-year surveillance colonoscopy, they will be asked for inclusion.

•Patients who:
•- have had an other bowel screening procedure pre-LT such as barium enema and/or sigmoidoscopy)
•- are unable or not willing to give informed consent
•- do have coagulopathy (prothrombin time < 50% of control; partial thromboplastin time > 50 seconds) or patients who have anticoagulants (marcoumar or sintrom) that can not be stopped
•- are under 18 years of age
•- have had auxiliary LTx
•- have PSC
•- are known with IBD ( UC or Crohn*s disease)
•- have undergone a total colectomy
•- do not have a post-LTx follow-up colonoscopy and are dead at time of inception

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