Prognosis of Bronchiectasis in Children--A Multicenter Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Change from baseline in lung function on the spirometry
研究概览
简要总结
This prospective cohort study is designed to observe of the effect of intervention therapy on the long-term prognosis of children with bronchiectasis. The main purpose of the study was to evaluate the degree of deterioration of lung function, to observe and compare the quality of life, the time of pulmonary exacerbation, and the changes of lung image.
详细描述
All enrolled patients are followed up for half a year, 1 years, 2 years, 3 years, 4 years, 5 years, while observation of pulmonary function, symptoms, signs, quality of life, the times of acute pulmonary exacerbation, and the changes of lung image are performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A included patient must be coincident at least one point of the four items of high-resolution computed tomography (HRCT) manifestations.
- •Internal bronchial diameter greater than the accompanying pulmonary artery.
- •lack of bronchial tapering
- •bronchi visible in the peripheral 1cm of lung
- •bronchial diameter greater than adjacent segmental bronchi
排除标准
- •Subject will be excluded if she or he has one of the following
- •It is unable or doesn't agree to accept the follow-up process
- •undergoing trial for other medications or instruments.
结局指标
主要结局
Change from baseline in lung function on the spirometry
时间窗: 5 years
forced expiratory volume at one second (FEV1) in Liter
次要结局
未报告次要终点
研究者
Baoping XU
Chief of Respiratory Department
Beijing Children's Hospital