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临床试验/NCT05170373
NCT05170373已完成不适用

Effects of Ultrasound Guided Erector Spinae Plane Block in Radical Prostatectomy Surgery on Pain and Surgical Stress Response

Istanbul Medeniyet University1 个研究点 分布在 1 个国家目标入组 46 人开始时间: 2019年2月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
46
试验地点
1
主要终点
prolactin

研究概览

简要总结

Our study aimed to examine the effects of ultrasound guided erector spinae plane block in radical prostatectomy surgery on pain and surgical stress response, to reduce adrenocortical and sympathetic discharge due to anesthesia and surgery, and to reduce peroperative opioid analgesic consumption.

详细描述

In this study 46 patients between the ages of 30-74, American Society of Anesthesiologists (ASA) score I-II and undergoing radical prostatectomy surgery at T.R. Ministry Of Health İstanbul Göztepe Prof. Dr. Süleyman Yalçın City Hospital were included. The patients were randomly divided into two groups as ESPB applied Group B (n=23) and not Group K (n=23). Patient-controlled analgesia (PCA) was initiated in all patients for postoperative analgesia. Patients' demographic data (age, gender, ASA score), intraoperative hemodynamic data, intraoperative and postoperative additional narcotic consumption, postoperative Numeric Rating Scale (NRS) scores (postoperative 0, 5 and 20 minutes and Then, 1, 3, 6, 12, 18 and 24 h), postoperative nausea-vomiting scores and possible complications related to block and / or surgery were recorded.Intraoperative MAP, HR, SpO2, BIS values of patients in both groups were recorded every 5 minutes. Blood glucose, insulin, cortisol, prolactin and C-reactive protein (CRP) were studied three times; preop morning at 6:00, intraoperative when surgical incision closing and postoperative 24h. in order to evaluate the surgical stress response in the patients.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

入排标准

年龄范围
30 Years 至 74 Years(Adult, Older Adult)
性别
Male
接受健康志愿者

入选标准

  • 未提供

排除标准

  • coagulopathy
  • local anesthetic
  • drug allergy
  • long hospitalization history,
  • hormone disorder
  • advanced organ failure
  • history of steroid use
  • vertebral anomalies
  • mental retardation

结局指标

主要结局

prolactin

时间窗: postoperative 24 hours.

µg/L

cortisol

时间窗: postoperative 24 hours.

µg/dL

Numeric Pain Scale

时间窗: postoperative 24 hours.

Between 1-10. 1: no pain, 10: worst possible pain

insulin

时间窗: postoperative 24 hours.

µIU/mL

C-reactive protein

时间窗: postoperative 24 hours.

mg/L

Blood glucose

时间窗: postoperative 24 hours.

mg /dL

次要结局

  • Remifentanil Consumption Speed(3 hours)

研究者

发起方
Istanbul Medeniyet University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Damla Turan

Principal Investigator

Istanbul Medeniyet University

研究点 (1)

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