NCT02271971已完成不适用
Effect of Vitamin D Supplementation on Metabolic Parameters of Patients With Moderate to Severe Psoriasis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Change in Total Cholesterol Levels
研究概览
简要总结
The purpose of this study is to determine whether supplementation with oral vitamin D (cholecalciferol) improves metabolic parameters in patients with moderate to severe psoriasis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of moderate to severe psoriasis.
- •Being treated with methotrexate with stable doses for al least 1 month.
排除标准
- •Phototherapy within the past 2 months.
- •History of psoriatic arthritis, rheumatoid arthritis, type 1 diabetes mellitus or inflammatory bowel disease.
- •Use of vitamin d supplements or fish oil supplements in the past 2 months.
- •Use of hypolipidemic drugs, hypoglycemic drugs, glucose sensitizers, oral corticosteroids, orlistat, cholestyramine, phenobarbital or phenytoin within the past 2 months.
- •Pregnancy or lactation.
结局指标
主要结局
Change in Total Cholesterol Levels
时间窗: Baseline and 6 weeks
次要结局
- Change in Fasting Glucose Levels(Baseline and 6 weeks)
- Change in Low-Density Lipoprotein Levels(Baseline and 6 weeks)
- Change in High-Density Lipoprotein Levels(Baseline and 6 weeks)
- Change in Triglycerides Levels(Baseline and 6 weeks)
- Change in C-Reactive Protein Levels(Baseline and 6 weeks)
- Change in Vitamin D Levels(Baseline and 6 weeks)
- Change in PASI (Psoriasis Area Severity Index)(Baseline and 6 weeks)
- Change in HOMA Index(Baseline and 6 weeks)
- Change in Glycated Hemoglobin Levels(Baseline and 6 weeks)
研究者
研究点 (1)
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