A Pilot Study on Gastric Layering and Emptying Induced by a Palaeolithic Inspired Meal
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4
- 试验地点
- 2
- 主要终点
- Volume of gastric content
研究概览
简要总结
This exploratory study is designed to compare the gastric layering and rates of emptying and by inference rates of digestion of a Palaeolithic inspired meal and a reference meal. Two types of meals, one high in fruit and vegetables will be used, and one based on WHO nutritional guidelines. Previous data suggests that the former meal releases nutrients more slowly than the latter. On each of two study days, a total of 11 MRI scans will be taken, 1 baseline and 10 post meal, to assess gastric layering and emptying. Participants will also be asked to complete a questionnaire at predetermined times to assess feelings of satiation.
详细描述
This study will be led by Dr Alan Mackie at the Institute of Food Research and supported by Dr Paul Malcolm at the Radiology Department at the Norfolk and Norwich University Hospital Foundation Trust (NNUHFT) and meals will be prepared under the supervision of Dr Frances Bligh at Unilever Research.
The recruitment of participants will be carried out by Alan Mackie at the Institute of Food Research in Norwich. Four apparently healthy participants will be recruited onto the study. Apparently healthy male participants with BMI between 19 and 35 will be recruited either by advertisement or identified from the Institute of Food Research (IFR) Human Nutrition Unit (HNU) Volunteer Database.
Preliminary telephone interview with Alan Mackie, the chief investigator will establish inclusion/exclusion criteria of potential participants who respond to the advertisement and/or the invitation letter. Potential participants will be invited to attend an interview at the HNU at IFR to meet the chief investigator to discuss the study protocol, test meals and to ask any question they have about the study. They will then have a minimum of 72 hours to consider their participation. They will be asked to contact the chief investigator if they are still interested and they will not be contacted by anyone from the research team during this time.
After the participant's response, a next visit will be arranged at the IFR HNU to obtain written consent (Annex 4) and complete an MRI safety questionnaire (Annex 10). The consent will be taken by the Chief Investigator or Senior Research Nurse. Participants consent is a requirement of the screening procedure, during which weight, height and blood pressure will be assessed. Enrollment is contingent on a screening questionnaire (Annex 5) and simple screening (urine dipstick), carried out by the HNU research nurse.
If a participant decides to join the study, the appointment will be made for their Study Test Day at the Radiology Department at the NNUHFT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male (hormonal status of women would introduce more variation within small group) Age 20-50y BMI 19-35 kg/m2 Apparently healthy Normally eat lunch and breakfast Provide written informed consent
排除标准
- •The subject is line managed the any members of the study team either at IFR or NNUH Radiology or a student with a dependency on any member of the NNUH study team, or is related to or living with any member of the study team.
- •Individuals with an intense dislike of or intolerance / allergy to any of the constituents of the test meal
- •Smokers or smoked within the last year (smoking affects satiety/hunger)
- •Diagnosed with any long term illness requiring active treatment e.g. diabetes, cancer, cardiovascular disease
- •Have had surgery on the stomach or intestine or suffered from oesophageal or gastrointestinal disease, whether diagnosed or self-reported
- •Regular (more than once in 10 days) use of antacids, laxatives
- •Any problems with swallowing
- •Take medication for digestive or gastrointestinal conditions.
- •Participants taking part in another study (other than a questionnaire based study).
- •Blood pressure greater than 160/100 mmHg or less than 90/50 or 95/55 mmHg if symptomatic.
- •Individuals with special dietary requirements (eg vegetarians)
- •If any of the clinical screening results are indicative of a health problem which would affect the participants well-being or which would affect the study data.
- •Refusal to give permission to inform GP of participation in study
- •Recent unexplained weight gain or loss
- •History of back problems or any other condition which limit ability to repeatedly sit up and lie down
- •Hiatus Hernia
- •MRI scanning specific exclusion criteria
- •Cardiac pacemaker or artificial heart valve
- •Any surgery in the last 6 months
- •Aneurysm clips (metal clips from surgery)
- •Implant, pump or any medical device in the body (eg cochlear implant, neurostimulator, intra-venticular shunt)
- •Worked with metals (using lathes or grinders) or sustained injury to eyes involving metal splinters or fillings
- •Have artificial eyes or limbs
- •Have been injured with shrapnel or bullets
- •Have a metal tattoo
- •Suffer from fits, blackouts or epilepsy
- •Claustrophobia sufferer
结局指标
主要结局
Volume of gastric content
时间窗: Every 20 mins for 3 hours
Three dimensional MRI data will be used to determine the volume of gastric content at each time point and thus allow the calculation of gastric emptying rate
次要结局
- Satiety response(Every 20 minutes for 3 hours)