ACTRN12626000814370招募中不适用
Validation of Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) assays as a traumatic brain injury (TBI) prognostication marker
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（—）
- 性别
- All
入选标准
- •Patients admitted to the ICU who:
- •Are less than 24 hours since suffering from a traumatic brain injury
- •Are expected to stay in the ICU for more than 48 hours
- •Are between 18 and 80 years old
- •Have CT brain imaging evidence of presence of traumatic brain injury
排除标准
- •Conditions which will cause a rise or alterations in GFAP and UCH-L1 levels independent of the TBI:
- •Spinal Cord Injury (radiological evidence)
- •A known central nervous system (CNS) and/or paraneoplastic malignancy.
- •Acute Kidney Injury (Creatinine levels greater than 1.5x baseline) or End-stage renal failure (receives chronic dialysis)
- •Pre-existing neurodegenerative disease (Parkinson’s, Alzheimer’s, Lewy body, etc.)
- •Cardiac arrest / suspected hypoxic-ischaemic encephalopathy.
- •Pregnancy/lactation/=3 months postpartum
- •Massive transfusion in the previous 12 hours
- •Conditions that may interefere with the ability to assess outcomes:
- •Severe pre-existing physical or mental disability or severe comorbidity that may interfere with the assessment of outcome.
研究组 & 干预措施
a) Overview of information collected
干预措施: a) Overview of information collected
研究者
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