Priming Effects of Aerobic Exercise on Cognitive Training of Patients With Ischemic and Hemorrhagic Stroke
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Neuropsychological test scores
研究概览
简要总结
The goal of this clinical trial is to test the effects of aerobic exercise and BDNF on patients with ischemic and hemorrhagic stroke during a computerized cognitive training.
The main questions it aims to answer are:
- Does a moderate intensity aerobic exercise, prior to a cognitive training, allow a better performance?
- Is it possible to exploit the timing of rehabilitation interventions to obtain greater effects? Participants will be divided in 2 groups. The experimental group will first perform 20 minutes of pedaling as a moderate intensity aerobic exercise. It will then participate in one-hour cognitive training sessions, with the aim of training attentional, working memory and executive functions. The control group will carry out the same interventions but in reverse order.
The researchers will compare the results of the cognitive training in the two groups to verify if the order of the interventions influences the results themselves.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with a clinical diagnosis of stroke, both ischemic and haemorrhagic.
- •Patients admitted to the Specialist Rehabilitation Unit 1 of the "E. Spalenza - Don Gnocchi "of Rovato.
- •Overall score in the MoCA test ³ 26
- •In case of a diagnosis of aphasia, a test of verbal comprehension ("Token Test") with score in the norm, P.E. > 1
- •Hypertonic and spasticity picture compatible with the performance of motor activity of pedaling expected in the EA session.
- •Tolerance of physical exercise
- •Incoming electrocardiogram normal and free of anomalies
排除标准
- •Overall score in the MoCA test <26
- •In case of a diagnosis of aphasia, a test of verbal comprehension ("Token Test") with pathological or borderline score, P.E. £
- •Documented diagnosis of neurodegenerative diseases with impact on performance cognitive.
- •Severe acquired brain injury
- •Illiteracy
- •Status of hypertonus and spasticity not compatible with the performance of motor training
- •Excessive fatigue: the patient does not tolerate moderate intensity physical activity and accuses excessive fatigue during the preliminary test
- •Electrocardiogram at entrance with anomalies and / or altered
- •Ischemic heart disease
- •Cardiac disorders that are contraindications for aerobic activity of moderate intensity
研究组 & 干预措施
Experimental Group
The experimental group will first perform 30 minutes of pedaling as a moderate intensity aerobic activity. Subsequently it will carry out a daily cognitive training of 60 minutes to improve attentional, working memory and executive functions.
干预措施: Neuropsychological evaluation (Behavioral)
Experimental Group
The experimental group will first perform 30 minutes of pedaling as a moderate intensity aerobic activity. Subsequently it will carry out a daily cognitive training of 60 minutes to improve attentional, working memory and executive functions.
干预措施: BDNF evaluation (Biological)
Experimental Group
The experimental group will first perform 30 minutes of pedaling as a moderate intensity aerobic activity. Subsequently it will carry out a daily cognitive training of 60 minutes to improve attentional, working memory and executive functions.
干预措施: Pedaling as a moderate intensity aerobic exercise (Behavioral)
Experimental Group
The experimental group will first perform 30 minutes of pedaling as a moderate intensity aerobic activity. Subsequently it will carry out a daily cognitive training of 60 minutes to improve attentional, working memory and executive functions.
干预措施: Cognitive Training (Other)
Experimental Group
The experimental group will first perform 30 minutes of pedaling as a moderate intensity aerobic activity. Subsequently it will carry out a daily cognitive training of 60 minutes to improve attentional, working memory and executive functions.
干预措施: VO2 assessment (Diagnostic Test)
Control Group
The control group will first carry out a daily 60-minute cognitive training to improve attentional, working memory and executive functions. It will then perform 30 minutes of pedaling as a moderate intensity aerobic activity.
干预措施: Neuropsychological evaluation (Behavioral)
Control Group
The control group will first carry out a daily 60-minute cognitive training to improve attentional, working memory and executive functions. It will then perform 30 minutes of pedaling as a moderate intensity aerobic activity.
干预措施: BDNF evaluation (Biological)
Control Group
The control group will first carry out a daily 60-minute cognitive training to improve attentional, working memory and executive functions. It will then perform 30 minutes of pedaling as a moderate intensity aerobic activity.
干预措施: Pedaling as a moderate intensity aerobic exercise (Behavioral)
Control Group
The control group will first carry out a daily 60-minute cognitive training to improve attentional, working memory and executive functions. It will then perform 30 minutes of pedaling as a moderate intensity aerobic activity.
干预措施: Cognitive Training (Other)
Control Group
The control group will first carry out a daily 60-minute cognitive training to improve attentional, working memory and executive functions. It will then perform 30 minutes of pedaling as a moderate intensity aerobic activity.
干预措施: VO2 assessment (Diagnostic Test)
结局指标
主要结局
Neuropsychological test scores
时间窗: Change in the neuropsychological test scores at 1 month
The experimental hypothesis is to obtain better scores in the experimental group on the neuropsychological tests used. T-tests and delta scores will be used to determine the quantitative change in the score.
次要结局
- Number of errors committed in the cognitive exercises(One month)