Impact of Prophylactic High Flow Nasal Oxygen in Post-Operative Thoracic Surgical Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- Number of Participants With Post-operative Pulmonary Complications
研究概览
简要总结
The Investigators goal was to study the effect of high flow nasal cannula oxygen (HFNC) on the rate of post-operative pulmonary complications in thoracic surgical patients. The Investigators hypothesis is that prophylactic HFNC oxygen, as compared to standard oxygen treatment, will reduce the incidence of postoperative pulmonary complications, improve post-operative pulmonary function, and reduce Intensive Care Unit (ICU) and hospital length of stay.
详细描述
The Investigators goal was to study the effect of high flow nasal cannula oxygen (HFNC) on the rate of post-operative pulmonary complications in thoracic surgical patients. The Investigators hypothesis is that prophylactic HFNC oxygen, as compared to standard oxygen treatment, will reduce the incidence of postoperative pulmonary complications, improve post-operative pulmonary function, and reduce ICU and hospital length of stay.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Undergoing Thoracic surgery
- •Planned admission to ICU after surgery
排除标准
- •Younger than 18
- •Breast feeding
- •Known diagnosis of obstructive sleep apnea
- •Current or previous lung transplant
- •Pneumonectomy
- •Home oxygen greater than 4L/minute
- •Inability to adhere to assigned treatment prior to 48 hours of surgery or until transferred to a floor
研究组 & 干预措施
Heated humidified high-flow nasal cannula (HHFNC) oxygen
The intervention group received HHFNC O2 at a set flow of 40L/min. FiO2 was titrated by respiratory therapists to maintain SpO2 ≥ 90%. The HHFNC O2 apparatus included: 1) Air-Oxygen blender - capable of delivering 21-100% FiO2 at flow rates up to 60L/min, 2) Heated Humidifier - providing active heating and humidification to the delivered air-O2 blend, 3) Nasal cannula - larger diameter, slightly elongated nasal cannula with single limb connection to humidifier
干预措施: Heated humified high-flow nasal cannula Oxygen (Device)
Standard oxygen Therapy
The standard O2 treatment group received usual nasal cannula or face mask oxygen titrated by nurses as necessary to maintain SpO2 ≥ 90%.
干预措施: Standard oxygen therapy (Other)
结局指标
主要结局
Number of Participants With Post-operative Pulmonary Complications
时间窗: 30 days
The primary outcome "post-operative pulmonary complication" is defined as present if any one of the following criteria are met: * SpO2 \< 90% with FiO2 ≥ 50% * Dyspnea at rest * Respiratory rate \> 25 breaths/min * Active use of accessory respiratory muscles * PaO2/FiO2 ratio \< 200 * Escalation of therapy to non-invasive ventilation * Re-intubation * Occurrence of hospital-acquired pneumonia * Re-admission to the ICU
次要结局
- ICU Length of Stay(30 days)
- Hospital Length of Stay(30 days)
- Lowest Oxygen Saturation Level Measured(30 days)