Effects of Early Cardiopulmonary Rehabilitation in Patients With Acute Decompensated Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Functional capacity
研究概览
简要总结
Acute decompensated heart failure (ADHF) is a severe condition characterized by rapid deterioration of cardiac function, leading to impaired oxygen delivery and multi-organ dysfunction. ADHF often results in reduced physical and respiratory capacity, greater dependence on oxygen support, difficulty performing daily activities, and prolonged hospital stays. In recent years, early exercise-based cardiopulmonary rehabilitation (CPR) has been introduced as part of heart failure management. Evidence suggests that early CPR improves overall health and cardiac function in heart failure patients. However, data regarding its effects in ADHF remain limited. While some studies indicate that early CPR enhances physical function, its impact on respiratory parameters and clinical outcomes is less well established.
Cardiopulmonary rehabilitation is a multidisciplinary program designed to promote physical, psychological, and social recovery in patients with cardiovascular and pulmonary diseases. It includes exercise training, education, psychosocial support, and behavioral strategies. Early CPR specifically aims to improve cardiovascular and respiratory functions in heart failure patients. Initiating CPR in the early phase of ADHF may accelerate recovery, strengthen cardiopulmonary function, shorten hospitalization, and improve quality of life.
This study aims to evaluate the effects of early CPR on functional capacity, hemodynamic parameters, and respiratory parameters in patients with ADHF.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients hospitalized with a diagnosis of acute decompensated heart failure
- •Being clinically stable
排除标准
- •Having diagnosed pulmonary, neurological, renal, liver, gastrointestinal, orthopedic or oncological pathologies
- •Having cardiomyopathy or congestive pericarditis
- •Recent heart surgery in the past 6 months
- •New or suspected thromboembolic event
- •Presence of open wounds, ulcerations or major dermatological diseases in the lower extremities
研究组 & 干预措施
Early cardiopulmonary rehabilitation group
Exercise-based cardiopulmonary rehabilitation will be applied to this group during the hospital stay every day for 3 times a day.
干预措施: Early Cardiopulmonary Rehabilitation (Other)
Early cardiopulmonary rehabilitation group
Exercise-based cardiopulmonary rehabilitation will be applied to this group during the hospital stay every day for 3 times a day.
干预措施: Routine in-hospital care (Other)
Control Group
Routine in-hospital care will be applied to this group.
干预措施: Routine in-hospital care (Other)
结局指标
主要结局
Functional capacity
时间窗: At baseline and at hospital discharge, up to 14 days after admission
It will be evaluated using 6-min walk test according to the guideline of American Thoracic Society
Physical performance
时间窗: At baseline and at hospital discharge, up to 14 days after admission
It will evaluated using Short Physical Performance Battery.
次要结局
- Maximum inspiratory and expiratory capacity(At baseline and at hospital discharge, up to 14 days after admission)
- Hemodynamic responses to exercise(At baseline and at hospital discharge, up to 14 days after admission)
- Subjective symptom responses to exercise(At baseline and at hospital discharge, up to 14 days after admission)
研究者
Melih Zeren
Associate Professor
Izmir Bakircay University