Long-term aspirin therapy as a predictor of decreased susceptibility to SARSCoV-2 infection in aspirin-exacerbated respiratory disease
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 76
- 试验地点
- 1
- 主要终点
- whether aspirin desensitization followed by long-term high-dose aspirin therapy in patients with AERD associated with lower gene expression of ACE2, TMPRSS2, BSG, PPIA, PPIB, DPP4, IFNA1, IFNB1 IFNG, IFNL1 i IFNL2 and ISG in sputum and nasal cells.
研究概览
简要总结
to determine whether treatment with aspirin, which inhibits cyclooxygenase-1 enzyme, can serve as a predictor of decreased susceptibility to SARS-CoV-2 infection and COVID-19 in patients with AERD. 2. to assess genetic features that might predict or attenuate SARS-CoV-2 infection on high-dose aspirin therapy.
入排标准
- 年龄范围
- 18 years 至 65+ years（18-64 Years, 65+ Years）
- 接受健康志愿者
- 是
入选标准
- •INCLUSION CRITERIA FOR AERD PATIENTS:* signed informed consent form * 18-70 years old AERD patients with baseline FEV1 of at least 70% of the predicted value on the challenge/desensitization day * no pregnancy, higly effective contraception must be used
- •INCLUSION CRITERIA FOR HEALTHY CONTROL: * signed informed consent form * 18-70 years old and healthy condition * no asthma
排除标准
- •failure of the circulatory and respiratory system, liver, kidneys and other vital organs
- •diabetes, cancer, systemic diseases of connective tissue, infectious diseases, coagulation disorders, active peptic ulcer disease, any active bleeding process.
- •Use of drugs that interact with aspirin
- •use of intoxicants, alcohol abuse, active and passive smoking
- •pregnancy, lactation
- •hypersensitivity to the active substance or any of the excipients
结局指标
主要结局
whether aspirin desensitization followed by long-term high-dose aspirin therapy in patients with AERD associated with lower gene expression of ACE2, TMPRSS2, BSG, PPIA, PPIB, DPP4, IFNA1, IFNB1 IFNG, IFNL1 i IFNL2 and ISG in sputum and nasal cells.
whether aspirin desensitization followed by long-term high-dose aspirin therapy in patients with AERD associated with lower gene expression of ACE2, TMPRSS2, BSG, PPIA, PPIB, DPP4, IFNA1, IFNB1 IFNG, IFNL1 i IFNL2 and ISG in sputum and nasal cells.
次要结局
- Whether the change of gene expression during aspirin therapy is connected with lower risk of SARS-CoV-2 infection
研究者
Prof. Lucyna Mastalerz
Scientific
Uniwersytet Jagiellonski Collegium Medicum