Hookworm infestation as therapy in Crohn's disease

niversity of Nottingham (UK)0 个研究点目标入组 56 人开始时间: 2006年8月4日最近更新: 2017年8月21日

适应症

试验速览

暂无简介。

•1. Diagnosis of moderately active Crohn's disease (CDAI between 220 and 450) requiring outpatient treatment
•2. Clinically acceptable baseline screening tests
•3. Aged between 18 and 80
•4. Have given written informed consent

•1. Positive stool culture for enteric pathogens or Clostridium difficile
•2. Bowel perforation, or obstructive symptoms not due substantially to active inflammation
•3. Patients whose diarrhoea is believed to be due to short bowel syndrome or bile salt malabsorption (making the CDAI invalid)
•4. Female patients of child bearing potential who are not willing or able to use at least one highly effective contraceptive method throughout the study. In the context of this study, an effective method is defined as those which result in low failure rate (i.e. less than 1% per year) when used consistently and correctly such as: implants, injectables, combined oral contraceptives, sexual abstinence or vastectomised partner
•5. Concomitant immunosuppressive therapy (cyclosporin in the last three months, methotrexate in the last six months, prednisolone more than 10 mg/day) or infliximab in the past three months. Azathioprine is permitted if the patient has been on a stable dose for at least two months
•6. Serious intercurrent infection or other active disease up to three months prior to treatment
•7. Known Human Immunodieficiency Virus infection

发起方

niversity of Nottingham (UK)