NCT07581860尚未招募不适用
Growth Hormone Resistance of Beta-cells in People With Impaired Fasting Glucose vs Impaired Glucose Tolerance
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
- 试验地点
- 1
研究概览
简要总结
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with impaired fasting glucose or impaired glucose tolerance at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing type 2 diabetes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •body mass index >18.5kg/m2 and <45.9kg/m2
- •impaired fasting glucose >/= 100mg/dL, </= 126mg/dL or impaired glucose tolerance on 75g oral glucose tolerance test (blood glucose 140 to 199mg/dL at two-hours)
排除标准
- •pregnant, planning to become pregnant during the study, or breastfeeding
- •current diagnosis or history of type 1 or type 2 diabetes
- •use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
- •history of bariatric surgery
- •known, uncontrolled hypothyroidism
- •history of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
- •current cancer or cancer that has been in remission less than 5 years
- •first degree relative with type 1 diabetes
- •evidence of anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
- •alcohol use disorder, use of controlled substances, or smoking >2 cigarettes per day
- •greater than 3% weight loss within three months of screening or engaged in regular (>/= 3 days per week), continuous moderate- or high-intensity exercise of >/= 30 min duration
- •mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent
研究组 & 干预措施
Impaired fasting glucose
Impaired glucose tolerance
研究者
Bettina Mittendorfer
Senior Associate Dean for Research; Professor, Medicine & Nutrition; NextGen Director of Clinical and Translational Sciences Unit
University of Missouri-Columbia
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 DiabetesHealthyObesityNCT06571500University of Missouri-Columbia30
招募中
不适用
Growth Hormone Resistance of Beta-cells AGestational DiabetesHealthyObesityNCT06571487University of Missouri-Columbia30
Unknown
4 期
不同糖耐量人群患者血浆细胞因子水平及其基因表达ChiCTR-OCS-13003185国家自然科学基金及重庆市科委重点项目150
尚未招募
不适用
Study of glycemic abnormalities, beta cell function and insulin sensitivity in transfusion dependent thalassemia patients : Cross sectional study.CTRI/2025/09/095409DR POOJA PATIL50
进行中（未招募）
4 期
Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor AgonistsNCT07325435MaryAnn Banerji60