NCT02273024已完成不适用
Exercise Therapy for Patients Awaiting Allogeneic Hematological Stem Cell Transplantation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change in Physical Function
研究概览
简要总结
The investigators hypothesize that inactivity during the search for a donor may exacerbate current deconditioned states; subsequently, influencing risk factors for post-transplant complications that hinder the recovery phase.
This study is designed to investigate if exercise therapy administered prior to allogeneic hematologic stem cell transplantation (HSCT) can influence physical and psychological side-effects associated with HSCT. Approximately 6-weeks prior to HSCT, individuals will be randomized into either an exercise group or usual care group and followed until one year after HSCT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 17 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Medical indication: allogeneic stem cell transplantation at Princess Margaret Hospital
- •must be ambulatory without need for human assistance at time of recruitment
- •medically cleared to exercise by the transplant physician
- •demonstrates willingness to attend supervised sessions
- •sufficient in English to ensure safety of understanding prescribed exercise guidelines, or has access to an adequate non-familial interpreter
排除标准
- •another active malignancy
- •less than 4 weeks till the scheduled HSCT
- •refusal to be randomized
- •does not have the approval of their transplant physician
- •severe or unstable neurological, cardiorespiratory, musculoskeletal disease or mental illness
结局指标
主要结局
Change in Physical Function
时间窗: Baseline, 1 week pre HSCT, T100, 1yr post HSCT
Cardiopulmonary Capacity (VO2peak)
次要结局
- Change in Symptoms(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Treatment Side-effects(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Six-minute walk test(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Quality of Life(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Anxiety(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Depression(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Fatigue(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
- Change in Strength(Baseline, 1 week pre HSCT, T100, 1yr post HSCT)
研究者
研究点 (2)
Loading locations...
相似试验
招募中
不适用
A Home-based Exercise and Physical Activity Intervention After Liver Transplantation: Impact of Exercise IntensityLiver TransplantationPhysical FitnessNCT06302205Universitaire Ziekenhuizen KU Leuven147
已完成
不适用
Collaborative-care Intervention to Promote Physical Activity After Total Knee ArthroplastyOsteoarthritisNCT02075931University of Colorado, Denver45
已完成
不适用
Feasibility of Interval Exercise in BronchiectasisBronchiectasisNCT03920124University of Lincoln5
终止
1 期
ApoGraft for the Prevention of Acute Graft Versus Host Disease in Haploidentical Hematopoietic Cell Transplant RecipientsAcute Graft Versus Host DiseaseHaploidentical Hematopoietic Stem Cell TransplantNCT04006652Washington University School of Medicine4
招募中
不适用
An Extension to Assess the Effect of Expanded Dialysis on Patient Reported Symptoms Using LEVILEnd Stage Renal DiseaseNCT06032208London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's100