Effects of Intravenous Dexmedetomidine on Shivering After Cesarean Delivery Under Neuraxial Anesthesia - A Randomized Control Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Shivering
研究概览
简要总结
"After spinal anesthesia, some patients may experience shivering, which can be uncomfortable and even lead to complications. Dexmedetomidine is a medication that can help prevent or reduce this shivering.
Dexmedetomidine helps to:
- Reduces shivering and discomfort.
- Improves patient comfort and satisfaction.
- Regulates body temperature.
- Safe and effective.
详细描述
Post-spinal shivering is a common complication that occurs in 40-65% of patients undergoing spinal anesthesia. It is characterized by involuntary, rhythmic muscle contractions that can lead to discomfort, anxiety, and increased oxygen consumption.
The exact mechanisms underlying post-spinal shivering are not fully understood, but several factors contribute to its development:
- *Hypothermia*: Spinal anesthesia can cause a decrease in core body temperature, leading to shivering.
- *Sympathetic blockade*: Spinal anesthesia blocks sympathetic nerve fibers, causing vasodilation and decreased blood flow to the extremities.
- *Increased oxygen consumption*: Shivering increases oxygen consumption, which can be detrimental in patients with pre-existing cardiovascular or respiratory disease.
*Effects of Dexmedetomidine on Post-Spinal Shivering*
Dexmedetomidine, an alpha-2 adrenergic agonist, has been shown to effectively reduce post-spinal shivering. Its effects include:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Elective Cesarean section
- •Age limit 18 to 35 years
排除标准
- •Emergency cesarean delivery
- •hypersensitive to dexmedetomidine
- •Pateint with hear, renal, or hepatic diseases requiring follow up
- •Pre-eclemptic pateint
- •Patient with GA
- •Combined spinal epidural anesthesia
研究组 & 干预措施
Intervention group
Received intravenous dexmedetomidine
干预措施: Dexmedetomidine (Drug)
Control group
control group receive normal saline
干预措施: Normal Saline (Placebo) (Other)
结局指标
主要结局
Shivering
时间窗: 3 minutes following infusion
Crossley and Mahajan grading of intraoperative shivering Grade 0: no shivering grade 1:no visible muscle activity but piloerection, peripheral vasoconstriction, or both present grade 2: muscular activity in one muscle group grade 3: muscle activity in one than more muscle group
次要结局
未报告次要终点
研究者
Ghulam Fatima
Principal Investigator
Liaquat National Hospital & Medical College