Innovative 3D Preclinical Models for Mature B-cell Malignancies to Advance Personalized Immuno and Combination Therapies
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- To generate 3D culture models from patients with CLL, SMZL, HCL
研究概览
简要总结
Adult patients with chronic lymphocytic leukemia (CLL), splenic marginal-zone lymphoma (SMZL) and hairy cell leukemia (HCL) followed at participating clinical sites will be enrolled and undergo sampling of additional amount of blood during the blood draws performed as part of standard clinical care.
The project aims to develop and validate innovative patient-derived 3D bioprinted models that faithfully reproduce the key microenvironments of lymphoid tissues, enabling a more physiologically relevant study of mature B-cell malignancies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years
- •Diagnosis of CLL, SMZL or HCL
- •Participant is willing and able to autonomously give informed consent for participation in the study.
排除标准
- •- Participant is unable or unwilling to provide informed consent for participation in the study
研究组 & 干预措施
CLL
Patients diagnosed with CLL
HCL
Patients diagnosed with HCL
SMZL
Patients diagnosed with SMZL
结局指标
主要结局
To generate 3D culture models from patients with CLL, SMZL, HCL
时间窗: 36 months
≥50% 3D culture models generated from patients with CLL, SMZL and HCL, defined as cell viability \>80% per sample in standard condition
次要结局
未报告次要终点
研究者
Cristina Scielzo
Head, Malignant B cells biology and 3D modelling Unit
IRCCS San Raffaele