NCT01351675终止3 期
Bardoxolone Methyl Evaluation in Patients With Chronic Kidney Disease and Type 2 Diabetes: the Occurrence of Renal Events (BEACON)
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 终止
- 发起方
- Biogen
- 入组人数
- 2,185
- 主要终点
- Time-to-first event of the composite endpoint
研究概览
简要总结
This study assesses the efficacy of bardoxolone methyl relative to placebo in delaying progression to end-stage renal disease (ESRD) and cardiovascular deaths in patients with Stage 4 Chronic Kidney Disease (CKD) and type 2 diabetes receiving standard of care.
详细描述
Study Sponsor, originally Reata Pharmaceuticals, Inc., is now Reata Pharmaceuticals, Inc., a wholly owned subsidiary of Biogen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Screening eGFR ≥ 15.0 and < 30.0 mL/min/1.73 m2;
- •A history of type 2 diabetes; diagnosis should have been made at ≥ 30 years of age;
- •Male or female at least 18 years of age;
- •Treatment with an angiotensin converting enzyme (ACE)inhibitor and/or an angiotensin II receptor blocker (ARB)for at least 6 weeks prior to and during screening. Stable dose 2 weeks prior to and during screening. Patients not taking an ACE inhibitor and/or ARB because of a medical contraindication must have discontinued treatment at least 8 weeks prior to Screening Visit A;
- •Mean systolic blood pressure (SBP) must be ≤ 160 mmHg and ≥ 105 mmHg and mean diastolic blood pressure (DBP) must be < 90 mm Hg during screening; both mean SBP and mean DBP (determined as the average of three readings) must be within this range at two separate time points measured at least 4 days apart during the screening period (blood pressure may be re-evaluated once during an unscheduled visit);
- •Willing to practice methods of birth control (both male and female patients) during the entire study period and for at least 30 days after the last dose of the study drug is ingested;
- •Serum magnesium level must be ≥ 1.3 mEq/L (0.65 mmol/L) at Screening Visit B or during subsequent unscheduled visit during screening (serum magnesium level may be re-evaluated once during an unscheduled visit);
- •Willing and able to cooperate with all aspects of the protocol;
- •Willing and able to give written informed consent for study participation and provide consent for access to medical data according to appropriate local data protection legislation, allowing authorization to access medical records and describe events captured in the endpoints
排除标准
- •Type 1 diabetes mellitus (juvenile onset). If a history of diabetic ketoacidosis exists, a C-peptide level must confirm type 2 diabetes;
- •Known non-diabetic renal disease (e.g., polycystic kidney disease, focal segmental glomerulosclerosis) [nephrosclerosis superimposed on diabetic kidney disease is acceptable];
- •Ongoing clinical evidence suggesting non-diabetic renal disease other than nephrosclerosis;
- •History of a renal transplant or a planned transplant from a living donor during the study;
- •Albumin to creatinine ratio (ACR) greater than 3500 mg/g (395.5 mg/mmol);
- •Hemoglobin A1c level > 11.0% (97 mmol/mol) during screening;
- •Acute dialysis or acute kidney injury within 12 weeks prior to screening or during screening;
- •Clinical signs and/or symptoms of uremia and expected need for renal replacement therapy within 12 weeks following randomization, as assessed by the investigator;
- •Recently active cardiovascular disease defined as: a. Unstable angina pectoris within 12 weeks before study randomization; b. Myocardial infarction, coronary artery bypass graft surgery, or percutaneous transluminal coronary angioplasty/stent within 12 weeks before study randomization; c. Cerebrovascular accident, including transient ischemic attack within 12 weeks before study randomization; d. Current diagnosis of Class III or IV New York Heart Association (NYHA) congestive heart failure;
- •Clinical diagnosis of severe obstructive valvular heart disease or severe obstructive hypertrophic cardiomyopathy;
- •Atrioventricular block, 2o or 3o, not successfully treated with a pacemaker;
- •DAdministration of a contrast agent that may induce nephropathy within 30 days prior to study randomization or planned during the study;
- •Systemic immunosuppression for a total of > 2 weeks, cumulatively, within the 12 weeks prior to randomization or planned during the study;
- •Total bilirubin, aspartate aminotransaminase (AST) or alanine aminotransaminase (ALT) levels greater than the upper limit of normal (ULN), or alkaline phosphatase level greater than two times the ULN on ANY screening laboratory test result;
- •Female patients who are pregnant, intend to become pregnant during the study, or are nursing;
- •BMI < 18.5 g/m2
- •Known hypersensitivity to any component of the study drug;
- •Current history of drug or alcohol abuse as assessed by the investigator;
- •Clinically significant infection requiring intravenous administration of antibiotics or hospitalization within 6 weeks of screening or during screening;
- •Hepatitis B surface antigen positive;
- •Diagnosis or treatment of a malignancy in the past 5 years, excluding non-melanoma skin cancer and carcinoma in situ of the cervix or a condition highly likely to transform into malignancy during the course of the study;
- •A clinical condition that in the judgment of the investigator could potentially pose a health risk to the patient while involved in the study;
- •Participation in a clinical study involving any intervention within 30 days prior to randomization, concurrent participation in such a study, or participation in a prior clinical study involving bardoxolone methyl in any form;
- •Unable to communicate or cooperate with the investigator due to language problems, poor mental development or impaired cerebral function.
研究组 & 干预措施
Placebo
Placebo Comparator
干预措施: Placebo (Drug)
结局指标
主要结局
Time-to-first event of the composite endpoint
时间窗: Approximately 24 months
Time-to-first event of the composite endpoint consisting of: * ESRD (need for chronic dialysis or renal transplantation) * Cardiovascular death
次要结局
- Rate of change in estimated glomerular filtration rate (eGFR) over the duration of the study(Approximately 24 months)
- Time to first event in the composite cardiorenal endpoint(Approximately 24 months)
- Time to first hospitalization for heart failure(Approximately 24 months)
- Frequency, intensity, and relationship to study drug of adverse events and serious adverse events, as well as clinical and laboratory test abnormalities.(Approximately 24 months)
研究者
相似试验
已完成
2 期
Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIATIdiopathic Interstitial PneumoniaRespiratory Bronchiolitis Associated Interstitial Lung DiseaseIdiopathic Pulmonary FibrosisCryptogenic Organizing PneumoniaAcute Interstitial PneumonitisIdiopathic Lymphoid Interstitial PneumoniaIdiopathic Pleuroparenchymal FibroelastosisDesquamative Interstitial PneumoniaPulmonary Arterial HypertensionPulmonary HypertensionInterstitial Lung DiseaseSarcoidosisNCT02036970Biogen166
终止
3 期
Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYSTConnective Tissue Disease-Associated Pulmonary Arterial HypertensionNCT02657356Biogen202
进行中（未招募）
不适用
The Evaluation of Bardoxolone Methyl in Patients with Chronic Kidney Disease and Type 2 DiabetesChronic Kidney Disease Stage 4MedDRA version: 14.1Level: SOCClassification code 10038359Term: Renal and urinary disordersSystem Organ Class: 10038359 - Renal and urinary disordersEUCTR2010-022297-14-ATReata Pharmaceuticals, Inc1,600
进行中（未招募）
1 期
The Evaluation of Bardoxolone Methyl in Patients with Chronic Kidney Disease and Type 2 DiabetesChronic Kidney Disease Stage 4MedDRA version: 14.1Level: SOCClassification code 10038359Term: Renal and urinary disordersSystem Organ Class: 10038359 - Renal and urinary disordersEUCTR2010-022297-14-BEReata Pharmaceuticals, Inc2,000
进行中（未招募）
不适用
The Evaluation of Bardoxolone Methyl in Patients with Chronic Kidney Disease and Type 2 DiabetesChronic Kidney Disease Stage 4MedDRA version: 14.1Level: SOCClassification code 10038359Term: Renal and urinary disordersSystem Organ Class: 10038359 - Renal and urinary disordersEUCTR2010-022297-14-CZReata Pharmaceuticals, Inc2,000