NCT00591474终止不适用
The Influence of Probiotics on Vancomycin-Resistant Enterococcus
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Whether a positive VRE colonized patient becomes VRE negative after drinking yogurt with probiotics
研究概览
简要总结
Drinking probiotics in a the form of a yogurt drink will restore normal gastrointestinal (GI) bacteria in patients whose colon are colonized with vancomycin-resistant enterococcus (VRE).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •VRE positive patients with GI colonization
排除标准
- •Age less than 18 years
- •Patients who have had a bone marrow transplant
- •Extreme short bowel patients (less than 100 cm small bowel remaining)
- •Patients with active VRE infection but no GI colonization
- •Patients unable to eat and have no feeding access
- •Patients who do not have a power of attorney to give consent if they are unable to
研究组 & 干预措施
1
Experimental
VRE positive patients
干预措施: probiotics (Dietary Supplement)
2
Placebo Comparator
VRE positive patients
干预措施: yogurt (Dietary Supplement)
结局指标
主要结局
Whether a positive VRE colonized patient becomes VRE negative after drinking yogurt with probiotics
时间窗: 4 weeks
次要结局
- Time to VRE clearance(4 weeks)
- Sustainable effects of probiotics on VRE colonization(8 weeks)
- Any positive or negative effects on patients' hospital stay.(8 weeks)
研究者
Robert Martindale
MD, PhD
Oregon Health and Science University
研究点 (2)
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