Study of Olfaction / Vision Interactions in Expert and Novice Populations
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Brain activity
研究概览
简要总结
The aim of this research project is to better understand the reciprocal influence of visual and olfactory systems on cerebral activity evoked by odors and visual stimuli. Given the importance of olfacto-visual learning in expert situations, the degree of expertise in olfaction will also be considered. In addition, the investigators will try to better understand the differences between expert and non-expert populations in olfaction through different levels of approach: sensory, genetic and cerebral. To achieve this, the investigators will use psychophysical tests, genetic analyzes and a non-invasive technique, functional magnetic resonance imaging (fMRI) to measure the brain activity of human subjects - novices or experts in olfaction - in response to different visual and olfactory stimuli.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy volunteers
- •men and women, aged 18-85 years old
- •subjects with social security cover
- •expertise in olfaction for half of the subjects (60)
排除标准
- •subjects younger than 18 and older than 85
- •subjects with contraindications to fMRI, i.e. with pacemaker / insulin pump / metal prosthesis / intracerebral clip / neurosensory stimulator / implantable defibrillator / cochlear implants / ferromagnetic ocular or cerebral foreign body close to the nerve structures / ventriculoperitoneal neurosurgical bypass valves / braces and other non-removable metallic dental device / claustrophobic, non-cooperating or agitated subjects.
- •pregnant or breastfeeding women
- •subjects with known olfactory disorder
- •subjects with known neurological disorder
研究组 & 干预措施
Odors (food and non-food)
Odorants diluted in mineral oil.
干预措施: Odor presentation (for participants' perception) (Other)
Pictures (food and non-food)
Pictures of objects or scenes.
干预措施: Image presentation (for participants' perception) (Other)
结局指标
主要结局
Brain activity
时间窗: During the 2-hour testing session (one session per participant)
fMRI 3T scanner in CERMEP imaging center (Bron - see web link at the end of the document), allowing anatomical measures, connectivity between olfactory and other regions (DTI), activation pattern in olfactory and visual areas.
次要结局
- Response times(During the 2-hour testing session (one session per participant))
- Genotyping(Sampling during the 2-hour testing session (one session per participant), analyses within 6 years after sampling)
- Olfactory abilities(During the 2-hour testing session (one session per participant))
- Perception(During the 2-hour testing session (one session per participant))