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临床试验/NCT03218228
NCT03218228Unknown不适用

Evaluation of the Health of Peri-implant Tissues Around Immediately Placed Dental Implants in Aggressive Periodontitis Patients Versus Periodontally Healthy Individuals in Maxillary Esthetic Zone

Cairo University1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2017年6月10日最近更新:
适应症
干预措施

试验速览

阶段
不适用
入组人数
20
试验地点
1
主要终点
implant and peri-implant tissues health

研究概览

简要总结

The aim of the present study is to evaluate the health of immediately placed dental implants in aggressive periodontitis patients versus those placed in periodontally healthy individuals in the maxillary esthetic zone.

详细描述

Aggressive periodontitis is an enigmatic periodontal disease that characterized by massive and undeterminable periods of tissue destruction. It gets along well to young individuals with successive periods of disease activity. Aggressive bone destruction with limited plaque and calculus deposits usually detected. According to microbial theory, Aggregatibacter actinomycetemcomitans (A.a) and P. gingivalis (P. G) were claimed for such a disease. Patients of aggressive periodontitis have disturbed esthetic and masticatory function problems.

After wards, microbial theory was modified to enroll the genetic background that can be the cause behind the developed body resistance. Although the importance of the genetic treatment to improve the body response, it was totally dismissed during the routine periodontal work attributable to high cost effectiveness of the needed genetic analysis especially in developing countries.

Further researches tried to explain the cause behind the impaired body response. Impaired functions of the immune cells and the massive amounts of catabolic cytokines such as IL-1, IL-6, Il-17, TNF- α and prostaglan¬din E2 (PGE2) are usually released during the active periods of the disease. On the other hand, matrix-metalloproteinases are destructive enzymes that released in an uncontrollable manner. Host modulators were suggested to control the released of the destructive agents.

Immediate implant placement provides an efficient modality that shortens the dental management period. The aim behind immediate implant placement is the proper implant positioning to counteract the advanced bone resorption following extraction.

Periodontitis is considered an important risk factor for peri-implantitis. The pre-existing periodontitis must be treated prior to implant placement in order to avoid the bacterial accumulation in the periodontal lesions regardless the type of periodontitis. Local and systemic supportive therapy is strongly recommended in order to reduce the microbial colonies and post-operative bone loss.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Health Services Research
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • • Subjects aged above 18 years old.
  • Patients should be free from any systemic disease.
  • patients with good oral hygiene
  • completely or partially edenthulus patients

排除标准

  • Current and former smokers.
  • Pregnant females.
  • Patients with systemic diseases that may interfere with periodontal condition
  • Uncooperative patients

研究组 & 干预措施

implants in healthy individuals

Placebo Comparator

immediate placement of dental implants in individuals with healthy periodontium. the device is dental implants, radiographs, william's periodontal probe

干预措施: implants in periodontitis (Procedure)

implants in periodontitis patients

Experimental

immediate implantation in patients suffering from aggressive periodontitis. the device is the dental implants, radiographs, william's periodontal probe

干预措施: implants in periodontitis (Procedure)

结局指标

主要结局

implant and peri-implant tissues health

时间窗: 12 months following implant placement

it includes evaluation of the health of the placed implant in aggressive periodontitis patients and the surrounding alveolar bone and soft tissue. in other wards it evaluate the survival rate of the dental implants placed in aggressive periodontitis patients. the health condition of the placed implants are evaluated according to scale called health scale which include 5 categories in which probing depth, alveolar bone ressorption, mobility, pain and other items are measured).

次要结局

  • midfacial peri-implant mucosal level(12 months following implant placement)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

nermin mohammed ahmed yussif

principal investigator-faculty of oral and dental medicine

Cairo University

研究点 (1)

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