A randomized double blind sham controlled trial of targeted lowfrequency repetitive transcranial magnetic stimulation (rTMS) therapyin childhood and adolescent with focal onset refractory epilepsy ?

Child neurology DivisionDepartment of AIIMSNew Delhi0 个研究点目标入组 49 人开始时间: 待定最近更新: 2023年10月16日

试验速览

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•Children and adolescents of either sex aged 5 -18 years diagnosed with focal onset drug refractory epilepsy as per with ILAE 2017. Drug refractory epilepsy will be defined as = 1 seizure / week OR 4 seizures/month despite on = 2 appropriately chosen and optimally prescribed antiepileptic drugs.
•1.Duration of epilepsy for atleast 1 year
•2.Seizures of single semiology
•3.Majority (75%) of Interictal epileptiform discharges(SWI) arising over a single epileptogenic focus on sleep EEG
•Parents/ guardians willing to follow the treatment protocol of daily sessions for 10 days in 2 week with Sunday off and hospital follow up at 6 week and 10 weeks of total study period

•Hemispheric epilepsy syndromes such as Rasmeussen’s encephalitis Hemiconvulsion-hemiplegia epilepsy syndrome or Hemimegalancephaly.
•2.Diagnosed epileptic encephalopathy other than focal ESES (Electrical status epilepticus in sleep)
•3.Diagnosed progressive neurological disorder
•4.Previous epilepsy surgery or vagal nerve stimulation insertion.
•5.Patient waitlisted for epilepsy surgery within 6 months
•6.Presence of Metallic implants anywhere in the body

发起方

Child neurology DivisionDepartment of AIIMSNew Delhi