Combination of Remifentanil and Flurbiprofen in Sedation and Analgesia for ESWL of Pancreatic Stone
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Visual analogue score of pain
研究概览
简要总结
Extracorporeal shock wave lithotripsy (ESWL) of pancreatic stones has been described as an effective approach for stone drainage and pain relief, and general or epidural anesthesia has been reported for such procedure. Single infusion of remifentanil has been described in ESWL of urinary stones, but it has never been described in ESWL of pancreatic stones. Moreover, single infusion of remifentanil might induce several complications, such as postoperative nausea and vomiting. The investigators attended to investigated whether combination of flurbiprofen with remifentanil reduced remifentanil dose and attenuated the complications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged 18-65 years
- •ESWL indication was met
排除标准
- •patients with hypertension
- •patients compromised in cardiopulmonary function
- •patients undergoing ESWL for the second or more times
研究组 & 干预措施
Flur group
Patients in this group receive both infusion of flurbiprofen and remifentanil
干预措施: Flurbiprofen and remifentanil (Drug)
Rem group
Patients in this group receive single infusion of remifentanil with target concentration infusion.
干预措施: Remifentanil (Drug)
结局指标
主要结局
Visual analogue score of pain
时间窗: During ESWL procedure
次要结局
- Cardiovascular responses including blood pressure and heart rate(During ESWL procedure)