Effects of Different Cold Therapy Modalities on Muscular Recovery and Inflammatory Responses Following Exercise-induced Muscle Damage in Healthy Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- Change of knee extensors muscle maximal isometric voluntary contraction during 168h post exercise-induced muscle damage (EIMD), assessed using isokinetic dynamometer
研究概览
简要总结
Subjects were randomly placed in five groups: (1) single exposure at 5°C in cold water immersion, (2) single exposure at 15°C in cold water immersion, (3) multiple exposures at 10°C in cold water immersion, (4) whole body cryotherapy (WBC) at 110°C and (5) passive recovery (control group). The single exposure groups performed cold water immersion immediately after exercise-induced muscle damage (EIMD) for 20 minutes. The multiple exposures group performed cold water immersion immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes. The WBC group remained in the cabin immediately after EIMD for 3 min. The control group was not exposed to treatment after the EIMD protocol. The subjects were asked to visit the laboratory on seven occasions. The first visit was the familiarization of the subjects with experimental procedures and their anthropometric assessment. One week after familiarization, on visit two, volunteers performed the exercise-induced muscle damage (EIMD) protocol and they were allocated to one of experimental groups. Indirect markers of muscle damage and inflammatory responses were evaluated at baseline (pre), immediately post, 24h, 48h, 72h, 96h, and 168h following the EIMD protocol by measuring anterior thigh muscle swelling, isometric knee extensors peak torque, knee extensors muscle soreness, countermovement vertical jump and blood sample analyzes.
详细描述
To avoid circadian influences, subjects were asked to visit the laboratory always at the same time of day. Volunteers were asked to not perform any vigorous physical activities or unaccustomed exercise during the experiment period. In addition, they were instructed not to intake medications or supplements during the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •College students were eligible for inclusion.
排除标准
- •Exclusion criteria included a history of eccentric quadriceps exercise in the past 3 months
- •A history of quadriceps muscle tear
- •Neurological disease involving the lower limbs
- •Current lower-limb musculoskeletal injury and thigh skinfold thickness >20 mm..
- •Participants with potential vascular problems which cold therapy is contraindicated (eg, diagnoses of diabetes or Raynaud's disease) were also excluded
研究组 & 干预措施
single exposure at 5°C in CWI
The subjects of this group performed cold water immersion (CWI) immediately after exercise-induced muscle damage (EIMD) a single exposure at 5°C for 20 minutes.
干预措施: single exposure at 5°C in CWI (Other)
single exposure at 15°C in CWI
The subjects of this group performed CWI immediately after EIMD a single exposure at 15°C for 20 minutes.
干预措施: single exposure at 15°C in CWI (Other)
multiple exposures at 10°C in CWI
The subjects of this group performed CWI immediately, 24h, 48h and 72h after EIMD (once a day) for 20 minutes.
干预措施: multiple exposures at 10°C in CWI (Other)
whole body criotherapy (WBC)
The whole body criotherapy (WBC) group remained in the cabin immediately after EIMD for 3 minutes.
干预措施: whole body cryotherapy (WBC) (Other)
passive recovery
The control group was not exposed to treatment after the EIMD protocol.
干预措施: passive recovery (Other)
结局指标
主要结局
Change of knee extensors muscle maximal isometric voluntary contraction during 168h post exercise-induced muscle damage (EIMD), assessed using isokinetic dynamometer
时间窗: at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.
次要结局
- Change of the anterior thigh muscle swelling during 168h post EIMD, assessed using ultrasound device(at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.)
- Change of the knee extensors muscle soreness during 168h post EIMD, assessed using a Visual Analogue Scale(at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.)
- Change on the performance of countermovement vertical jump during 168h post EIMD, assessed using a force plate(at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.)
- Change of inflammatory response (Tumor Necrosis Factor-α, interleukin-6, interleukin-10, interleukin-1β, interleukin-1ra) during 168h post EIMD, assessed by blood sample analyzes(at baseline (pre) and at 0, 24, 48, 72, 96, and 168 hours after exercise-induced muscle damage.)
研究者
Angelina Freitas Siqueira
Angelina Freitas Siqueira
University of Brasilia