Effect of Ramadan Fasting on Muslim Recipients After Living Donor Liver Transplantation: Single Center Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Effect of fasting on Allograft function among recipients post liver transplantation
研究概览
简要总结
The study aimed to assess the possibility of Ramadan fasting and to start protocol of adapting immunosupression regiment and scheduled follow up for patients wishing to fast after liver transplantation (LT).
详细描述
Very limited data in the literature about how to apply Ramadan fasting in the post liver transplant setting. The timing of Ramadan is changeable according to the lunar year and according to time of down and sunset in each country. In Egypt, for example, Ramadan fasting this year started 17th of May and finished 14th June with average fasting hours of 15-16 hours The study aimed to assess the possibility of Ramadan fasting and to start protocol of adapting immunosupression regiment and scheduled follow up for patients wishing to fast after LT.This prospective study included 45 recipients who underwent LT at Ain Shams Center for Organ Transplant (ASCOT), Cairo, Egypt.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Recipients completed their first year after LDLT
- •Normal liver and renal functions at least in the last 3 months before fasting
- •No reported rejection episodes in the last 6 months before the study
- •Recipients wishing to fast Ramadan
- •Informed consent about the study
排除标准
- •• First year of LDLT
- •Recipients transplanted for Budd Chiari syndrome
- •Recipients with vascular stents (hepatic artery , portal vein or hepatic vein stents) requiring long life anticoagulation
- •Creatinine clearance <60 ml/min or serum creatinine >1.5 mg/dl at time of initial enrolment in the study.
结局指标
主要结局
Effect of fasting on Allograft function among recipients post liver transplantation
时间窗: 1 month
Comparison between pre and post fasting state as regards allograft lfunctions , reflected by measuring AST, ALT(liver enzymes) , serum bilirubin , serum albumin +\\_ liver biopsy if rejection is suspected
Effect of fasting Ramadan on renal functions among recipients post liver transplantation
时间窗: 1 month
Comparison between fasting and post fasting renal functions ( serum creatinine, Blood urea nitrogen ,serum sodium and potassium
Effect of Ramadan fasting on immunosuppressant trough level in liver transplantation recipients
时间窗: 1 month
Comparison between fasting and post fasting immunosuppressant drugs trough levels
次要结局
- Effect of fasting Ramadan on blood sugar control among diabetics recipients(1 month)
- Effect of Ramadan fasting on blood pressure Among hypertensive recipients on antihypertensive drugs(1 month)
研究者
Iman Fawzy Montasser
Associate professor of tropical medicine , Ain Shams university
Ain Shams University