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临床试验/NCT06510686
NCT06510686已完成不适用

Comparison of the Effects of Core Stabilization and Inspiratory Muscle Training on Diaphragm Activation, Inspiratory Muscle Strength, Functional Capacity, Respiratory Functions, Physical Activity and Quality of Life in Patients With COPD

Mustafa Ertuğrul Yaşa1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2024年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
36
试验地点
1
主要终点
Symptoms

研究概览

简要总结

In Chronic Obstructive Pulmonary Disease (COPD), a mismatch develops between the respiratory system's demand and the functional capacity of respiratory muscles due to the combination of local and systemic factors increasing the respiratory workload. This results in impaired coordination of muscle groups, leading to muscle dysfunction. Respiratory muscle dysfunction is a significant determinant of life expectancy in COPD. Additionally, respiratory muscles unable to cope with increased workloads lead to impaired respiratory functions and reduced exercise capacity.

It is widely accepted that appropriate training of respiratory muscles can increase their strength, endurance, and their close relationship with lung volume capacities. Besides their role in respiration, respiratory muscles also contribute to postural function and core stabilization. Studies on respiratory muscle training in COPD have primarily focused on inspiratory muscle strength training, neglecting the core stabilization function of respiratory muscles. However, optimal gains in a muscle can only be achieved with training tailored to its functional characteristics. Therefore, a comprehensive training program should be developed considering the multifunctional nature of respiratory muscles. Studies published in healthy individuals and different patient populations demonstrate that core training can improve lung functions. The aim of this study is to compare the effects of inspiratory muscle training and core stabilization training on diaphragm activation, inspiratory muscle strength, functional capacity, respiratory functions, physical activity, and quality of life in individuals with COPD.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 85 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Being over 18 years old
  • Having a diagnosis of COPD according to the GOLD criteria and being at stage 3 or lower
  • Not being in an acute exacerbation period and having at least one month since the last exacerbation
  • Being able to walk independently
  • Having sufficient mental capacity to understand the tasks in the study (Mini-Mental Test >24)
  • Being willing to participate in the study

排除标准

  • Being a stage 4 COPD patient according to the GOLD criteria
  • Having a diagnosis of lung cancer, pulmonary hypertension, and heart failure
  • Being in a COPD exacerbation period
  • Scoring below 24 on the Mini-Mental Test
  • Having any other disease that affects respiratory functions
  • Having undergone pulmonary surgery

结局指标

主要结局

Symptoms

时间窗: 8 weeks

MMRC Dyspnea Scale (Scores range from 0 to 4)

Inspiratory Muscle Strength

时间窗: 8 weeks

Maximal Inspiratory Pressure (MIP) (cmH2O),

Respiratory function tests PEF

时间窗: 8 weeks

Spirometry, PEF (lt/sn)

Inspiratory Muscle Activation

时间窗: 8 weeks

surface EMG (TLC from FRC (TLC maneuver)(cmH2O)

Respiratory function tests FEV1

时间窗: 8 weeks

Spirometry, FEV1 (lt)

Respiratory function tests FVC

时间窗: 8 weeks

Spirometry, FVC (lt)

Respiratory function tests FEV1/FVC

时间窗: 8 weeks

Spirometry, FEV1/FVC %

Respiratory function MVV

时间窗: 8 weeks

Spirometry, MVV(L/min)

Functional capacity

时间窗: 8 weeks

Six Minute Walking Test (6MVT) (m)

次要结局

  • Physical activity,(8 week)
  • Quality of life Tests(8 week)
  • Core Strength extension(8 week)
  • Core Strength(8 week)
  • Core Strength flexion(8 week)
  • Core Strength side bridge(8 week)

研究者

发起方
Mustafa Ertuğrul Yaşa
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Mustafa Ertuğrul Yaşa

assistant professor

Gulhane School of Medicine

研究点 (1)

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