Immunological Response After Shrimp Oral Immunotherapy Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change in Eliciting Dose of Shrimp During Oral Food Challenge
研究概览
简要总结
Oral immunotherapy is effective in desensitized food allergy. Shrimp allergy is increasing in Thailand. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to shrimp, Immunoglobulin G4 and immunoblot analysis in shrimp allergy patients after shrimp oral immunotherapy.
详细描述
All subject in this study were sensitized to shrimp. All patient was clinically evaluated, with focus on shrimp allergy by medical history, medical examination and gold standard oral food challenge test. Compare oral immunotherapy to shrimp and shrimp avoidance. Blood sample was taken for baseline determination of immunoglobulin E antibodies to shrimp. The primary outcome was the specific immunoglobulin E antibodies to shrimp,Immunoglobulin G4 and immunoblot analysis in case that oral immunotherapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 12 - 40 years old
- •History of Immunoglobulin E-mediated shrimp allergy > 3 episode/year or disturb quality of life
- •Positive oral food challenge test for shrimp
排除标准
- •History of shrimp anaphylaxis (include cardiovascular or neurological symptoms)
- •Shellfish dependent exercise induced anaphylaxis
- •History of cardiovascular disease, uncontrolled asthma, severe atopic dermatitis
- •History of Beta-blocker, Angiotensin-converting enzyme inhibitor, Angiotensin receptor blocker, Calcium channel blocker
研究组 & 干预措施
Shrimp allergy with Intend to eat shrimp
Case shrimp Immunoglobulin E mediated allergy and intend to eat shrimp and start oral immunotherapy for shrimp
干预措施: shrimp allergy with intend to eat shrimp (Other)
Shrimp allergy with avoid shrimp
Case shrimp allergy with avoid shrimp
结局指标
主要结局
Change in Eliciting Dose of Shrimp During Oral Food Challenge
时间窗: Baseline and 12 months
Change in the eliciting dose (ED) of shrimp protein during oral food challenge from baseline to 12 months in participants with shrimp allergy undergoing shrimp oral immunotherapy compared with avoidance.
specific Immunoglobulin E, Immunoglobulin G4, immunoblot analysis from Desensitized to shrimp allergen
时间窗: 1 year
To follow-up the level of specific Immunoglobulin E, Immunoglobulin G4, immunoblot analysis from Desensitized to shrimp allergen
次要结局
- Adverse Event From Shrimp Oral Immunotherapy(1 year)
- Adverse event from Shrimp oral immunotherapy(1 year)