NCT05621499进行中（未招募）不适用
The Safety and Efficacy of HAIC or Lenvatinib Combined With Sintilimab as a Neoadjuvant Therapy for High Recurrence Risk Resectable Stage IB Solitary Hepatocellular Carcinoma: a Prospective, Randomized, Two Cohort, Exploratory Study
Tianjin Medical University Cancer Institute and Hospital1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2022年12月20日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1-year DFS rate
研究概览
简要总结
To evaluate the safety and efficacy of HAIC or Lenvatinib combined with Sintilimab as a neoadjuvant therapy for high recurrence risk resectable stage IB solitary hepatocellular carcinoma
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Volunteer to join the study and signed the informed consent form
- •Aged 18-75, male or female
- •ECOG PS score 0-1
- •Child Pugh liver function Grade A
- •Histopathology confirmed primary hepatocellular carcinoma (HCC) and the lesion met the indications for surgical resection in the Diagnostic and Therapeutic Norms for Primary Liver Cancer (2022)
- •According to the investigator's assessment, there are the following high recurrence risk factors, Stage Ⅰ b: solitary tumor, with the largest diameter > 5cm
- •At least one measurable lesion according to RECIST 1.1 (measurable lesion CT/MRI scan length diameter ≥ 10mm or lymph node lesion CT/MRI scan short diameter ≥ 15mm, and measurable lesion has not received radiotherapy, cryotherapy and other local treatments)
- •Expected life ≥ 6 months
- •Functions of important organs shall meet the following requirements (excluding the use of any blood component and cell growth factor within 14 days) Neutrophils ≥ 1500/mm3Platelet count ≥ 60,000/mm3Hemoglobin ≥ 5.6 mmol/L (9 g/dL); Serum creatinine (SCR) ≤ 1.5 times the upper limit of normal value (ULN) or creatinine clearance ≥ 50 ml/min (Cockcroft Gault formula); Total bilirubin (TBIL) ≤ 1.5 times the upper limit of normal value (ULN); The level of AST or ALT ≤ 2.5 times the upper limit of normal value (ULN); Urine protein<2+; If urinary protein ≥ 2+, the 24-hour urine protein quantitative display must be ≤ 1g
- •Normal coagulation function, no active bleeding and thrombosis disease
- •International normalized ratio INR ≤ 1.5 × ULN；
- •Partial thromboplastin time APTT ≤ 1.5 × ULN；
- •Prothrombin time PT ≤ 1.5ULN;
- •Women of childbearing age should agree to use contraceptive measures (such as intrauterine devices, contraceptives or condoms) during the medication period and within 6 months after the end of medication; If the serum or urine pregnancy test was negative within 7 days before the study included, and the patient must be a non lactating patient, the male should agree to use contraception during the study period and within 6 months after the end of the study period
- •The subjects had good compliance and cooperated with follow-up.
排除标准
- •Previously received radiotherapy, chemotherapy, concurrent radiotherapy and chemotherapy or other targeted therapies
- •Known hepatobiliary cell carcinoma, sarcomatoid HCC, mixed cell carcinoma and fibrolamellar cell carcinoma; Have other active malignant tumors except HCC within 5 years or at the same time
- •Patients with hypertension who cannot be well controlled after antihypertensive drug treatment (systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg); Previous hypertension crisis or hypertensive encephalopathy
- •Patients had other malignant tumors in the past or at the same time (except cured skin basal cell carcinoma and cervical carcinoma in situ);
- •Patients who had been treated with Sintilimab or other PD-1/PD-L1 inhibitors in the past could not be included; Known hypersensitivity to macromolecular protein preparations or any excipients of Sintilimab or lenvatinib
- •Patients have any active autoimmune diseases or have a history of autoimmune diseases (Including but not limited to: autoimmune hepatitis, interstitial pneumonia, uveitis, enteritis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism; Patients with vitiligo or asthma in childhood has completely alleviated, without any intervention after adulthood can be included; Patients with asthma requiring medical intervention of bronchodilators cannot be included)
- •Patients who are using immunosuppressive agents, or systemic or absorbable local hormone to achieve immunosuppressive purpose (Dose>10mg/day prednisone or other equivalent therapeutic hormones) and continue to use them within 2 weeks before enrollment
- •Ascites or pleural effusion with clinical symptoms and requiring therapeutic puncture or drainage
- •There are clinical symptoms or diseases of the heart that are not well controlled, such as:
- •Heart failure above NYHA level 2
- •Unstable angina pectoris
- •Myocardial infarction occurred within 1 year
- •Clinically significant supraventricular or ventricular arrhythmia requiring treatment or intervention
- •Patients having gastrointestinal diseases such as esophageal varices, active gastric and duodenal ulcers, ulcerative colitis, portal hypertension, or active bleeding from tumors that have not been removed, or other conditions that may cause gastrointestinal bleeding and perforation as determined by the investigator at present (within 3 months)
- •Serious bleeding (>30 ml bleeding within 3 months), hemoptysis (>5 ml fresh blood within 4 weeks) or thromboembolism (including stroke and/or transient ischemic attack) occurred in the past or present
- •Patients with active infection or fever of unknown origin>38.5℃during the screening period and before the first administration (according to the judgment of the investigator, subjects with fever due to tumor can be included)
- •Patients with past or current objective evidence of pulmonary fibrosis history, interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-related pneumonia, and severe impairment of pulmonary function
- •Patients with congenital or acquired immune deficiency, such as HIV infection, or active hepatitis (transaminase does not meet the inclusion criteria: HBV DNA ≥ 10e4/ml; HCV RNA ≥ 10e3/ml); Chronic hepatitis B virus carriers with HBV DNA<2000 IU/ml (<10e4 copies/ml) receive antiviral treatment at the same time during the trial can be included
- •Live vaccine may be inoculated less than 4 weeks before the study medication or during the study period
- •Known history of abuse of psychotropic substances, alcohol abuse or drug abuse
- •Conditions should be excluded according to the judgment of the investigator, for example, according to the judgment of the investigator, the patient has other factors that may lead to the forced termination of the study, such as other serious diseases requiring combined treatment, serious laboratory examination abnormalities, and family or social factors, which may affect the safety of the subject, or the collection of data and samples.
研究组 & 干预措施
experimental group1
Experimental
HAIC
干预措施: HAIC (Drug)
experimental group 2
Experimental
Lenvatinib+Sintilimab
干预措施: Sintilimab (Drug)
experimental group 2
Experimental
Lenvatinib+Sintilimab
干预措施: Lenvatinib (Drug)
结局指标
主要结局
1-year DFS rate
时间窗: up to 1 years
To evaluate the 1-year disease free survival rate of neoadjuvant treatment with HAIC or Lenvatinib combined with Sintilimab for of high recurrence risk resectable stage IB solitary hepatocellular carcinoma
次要结局
- Incidence of microvascular invasion(Up to 3 years)
- Pathological complete response rate (pCR)(up to 1 years)
- Objective response rate(Up to 1 years)
- 2-year DFS rate(Up to 3 years)
- 2-year OS rate(Up to 3 years)
- Adverse Events (AEs)(Up to 3 years)
研究者
研究点 (1)
Loading locations...
相似试验
招募中
2 期
Clinical Study of Sintilimab Combined With Chemotherapy in Neoadjuvant Treatment of Non-small Cell Lung CancerNon-small Cell Lung CancerNCT05170581The Second Affiliated Hospital of Shandong First Medical University30
招募中
2 期
TACE/HAIC Combined With Lenvatinib and Sintilimab in Neoadjuvant Therapy for Intermediate-stage HCCHepatocellular CarcinomaNCT05250843Third Affiliated Hospital, Sun Yat-Sen University90
尚未招募
2 期
Neoadjuvant and Adjuvant Sintilimab Combined with Chemoradiotherapy Versus Chemoradiotherapy Alone in Stage TanyN3M0 Nasopharyngeal CarcinomaNasopharyngeal Carcinoma (NPC)NCT06680115First Affiliated Hospital of Guangxi Medical University150
已完成
不适用
HAIC Combined With Lenvatinib and Sintilimab for Hepatocellular Carcinoma With PVTTCarcinoma, HepatocellularLiver NeoplasmsSintilimabPortal Vein Tumor ThrombusNCT04618367Sun Yat-sen University30
招募中
3 期
Lenvatinib+Sintilimab+TACE vs. Lenvatinib+TACE for Advanced HCCHepatocellular Carcinoma Non-resectableNCT05608200Second Affiliated Hospital of Guangzhou Medical University427