Definitive Chemoradiation With Gemcitabine and Continuous 5- FU (Fluorouracil)Followed by High Dose Rate Brachytherapy or Stereotactic Body Radiation Therapy Boost in Locally Advanced Intra or Extrahepatic Cholangiocarcinoma

Cholangiocarcinoma is an uncommon tumor arising from the biliary tract. It can be stratified into two categories based on location, intrahepatic and extrahepatic. In the United States, approximately 4,000-5,000 cases of cholangiocarcinoma are diagnosed each year. The most common location is at the bifurcation of the common hepatic duct and is classified as extrahepatic, also known as a Klatskin tumor. Approximately 60-80% of tumors are found in this perihilar location. A history of primary sclerosing cholangitis confers 10% lifetime risk of developing cholangiocarcinoma. Other known risk factors include ulcerative colitis, liver fluke infestations, hepatolithiasis, thorotrast exposure and choledochal cysts. Cholecystectomy decreases the risk. Most patients are lymph node positive at diagnosis, approaching 55-60%, and less than half are resectable at diagnosis.

Because of the rare nature of the tumor, there are limited prospective trials addressing the roles for surgery, chemotherapy (CT) and radiation therapy (RT) in the treatment of cholangiocarcinoma. Despite advances in surgical and radiotherapy techniques, the prognosis for cholangiocarcinoma remains dismal. Historically, survival is poor with a 0-10% 5-year survival. In more recent years, a median survival of 2-15 months is expected. Patients who are able to undergo surgical resection at diagnosis have longer survival of approximately 20-24 months. Recent investigations in the area of neoadjuvant chemoradiation followed by orthotopic liver transplant in a select group of patients report promising results, with 1-, 3- and 5-year overall survival of 92%, 82% and 82%, respectively. Although this approach may be appropriate for select patients, namely younger patients with small tumors, no or limited nodal involvement, and no encasement of the major vasculature, the majority of patients presenting with cholangiocarcinoma will present with unresectable disease at initial diagnosis, often due to nodal involvement.

Chemotherapy The role of chemotherapy (CT) in cholangiocarcinoma has not been established. Most chemotherapy trials have been small single institution phase II trials, and there have been no large prospective randomized trials. Additionally, most chemotherapy trials include patients with intrahepatic, extrahepatic and gallbladder carcinomas, as well as patients with locally advanced and metastatic disease. Response rates have ranged from 0-40% with no complete remissions. The most extensively investigated CT agent has been 5-fluorouracil (5-FU), which has disappointing response rates of 9% as a single agent. Response rates were not improved by the addition of streptozotocin or methyl-CCNU (Semustine) to 5-FU in a randomized trial performed by Eastern Cooperative Oncology Group (ECOG).6 Multiple combination CT regimens have been investigated in small clinical trials, and none have shown a survival benefit.

Gemcitabine has shown some promise as a potential chemotherapeutic agent in the treatment of cholangiocarcinoma. A multicenter retrospective analysis out of Japan examining a multitude of different CT regimens in patients with intrahepatic, extrahepatic or gallbladder carcinomas reported gemcitabine was the most effective treatment, with a reduction in mortality by about 50%.7 Fifty-eight patients of the 413 identified in this study were treated with gemcitabine, 6.9% showed partial response, 50% remained stable, and 39.7% progressed despite therapy. Median survival was 8.05 months with a hazard ratio (HR) of 0.50 (95% confidence interval 0.35-0.72). Sixteen out of the 58 patients treated with gemcitabine had extrahepatic cholangiocarcinoma. In numerous phase II trials of gemcitabine as a single agent, response rates have ranged from 6-30%, with greater than 50% of treated patients having either a partial response or stable disease. 7-12 Median survival (MS) has ranged from 6.5-14 months in these trials. In 2008, guidelines for CT in biliary tract cancers were published in the Journal of Hepatobiliary and Pancreatic Surgery.13 Seven trials using gemcitabine as a single agent were identified, with response rates ranging from 0-36% and MS ranging from 4.6-14 months. In this article the use of gemcitabine in unresectable cancers of the biliary tract was given a recommendation level C1, meaning that its use may be considered, although there is a lack of high-level evidence.13

The combination of 5-FU or it's oral analog capecitabine and gemcitabine chemotherapy alone (without radiation) in the advanced metastatic setting has improved response rates and median overall survivals from around 10% or 6.1 months to 10-36% and 9.7 to 14 months respectively.13a Based on this data it likely should have synergy if both agents are given concurrently with external beam RT. The combination of continuous 5-FU and gemcitabine with external beam radiation in locally advanced pancreatic cancer has been shown to be safe and resulted in a complete response in 2 patients (6.3%), a partial response in 18 patients (56.3%), with an overall all response rate of 62.5% 13b. Based on this data and the similar dose of external RT therapy it seems reasonable and safe to combine the two agents 5-FU and gemcitabine with RT in advanced cholangiocarcinoma. We chose to use 5-FU rather than oral capecitabine due to occasional problems obtaining prescription coverage for this more expensive alternative and the prior available safety data and our own institutional experience using 5-FU and gemcitabine combination with RT for pancreatic cancer.