Iyengar Yoga as a Probe of Prolonged Grief Disorder Neurobiology
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- Change in circulating endocannabinoid concentrations
研究概览
简要总结
Experiencing the death of a loved one is inevitable for older adults. Before the coronavirus disease 2019 (COVID-19) pandemic, over 2.5 million people died annually in the United States, including 52,000 in Wisconsin alone, and COVID-19 has added to this toll. Each person who dies leaves an average of five grieving people behind. Most grieving older adults are resilient and recover their pre-loss functioning within one year. However, in about 10%, acute grief becomes protracted and debilitating, leading to the development of prolonged grief disorder (PGD), a clinically diagnosable mental health condition. PGD in older adults increases the risk for poorer medical, mental health, and cognitive outcomes; lower quality of life; disability; premature mortality; and suicide. Despite the magnitude of this problem, the neurobiology of PGD in older adults is poorly understood. By using Iyengar Yoga (IY) as a probe for PGD neurobiology, this pilot project aims to address this critical gap.
详细描述
Our goal is to conduct a pilot study to examine in PGD the modulating effects of 10-week IY on circulating endocannabinoid and emotion processing brain circuit, and the associations between biological changes and clinical response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female greater than or equal to 40 years of age
- •Bereavement >6 months
- •Score greater than or equal to 25 on the Inventory of Complicated Grief (ICG)
- •Presence of PGD (subsyndromal and syndromal)
- •Adequate visual and auditory acuity
排除标准
- •Delirium/unstable medical conditions
- •Lifetime history of neurological illnesses: seizures, stroke, dementia of any etiology, severe head injury, brain tumor or surgery
- •Serious back, joint or neck injuries within the past 3 months
- •Currently practicing yoga
- •Gross structural abnormalities on T1-weighted images
- •Lifetime history of the following psychiatric disorders: bipolar or psychotic disorders, including psychotic depression
- •Current alcohol/drug abuse or dependence
- •Magnetic resonance imaging (MRI) contraindications
- •Acute suicidality
研究组 & 干预措施
Iyengar Yoga
Participants will engage in 10 weekly IY classes
干预措施: Iyengar Yoga (Other)
Socialization Control
Participants will engage in 10 weekly socialization control group sessions
干预措施: Socialization Control (Other)
Healthy Comparison Group
A group of participants will also be followed for 10 weeks
结局指标
主要结局
Change in circulating endocannabinoid concentrations
时间窗: 10 weeks
Change in circulating endocannabinoids from baseline to post-intervention
次要结局
- Change in neural activity measured using Functional magnetic resonance imaging (fMRI)(10 weeks)
- Inventory of Complicated Grief (ICG) scale score change(10 weeks)
研究者
Joseph Goveas
Professor
Medical College of Wisconsin