Impact of Medication Adherence on Cardiovascular Outcomes in Individuals With Type 2 Diabetes and Disabilities: Nationwide Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 365,295
- 主要终点
- Major adverse cardiac and cerebrovascular events (MACCE)
研究概览
简要总结
Individuals with disabilities and type 2 diabetes tend to have worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators evaluated the role of medication adherence. A retrospective, cohort study was conducted using data from the Korean National Health Insurance Service (K-NHIS) database.
详细描述
Type 2 diabetes mellitus (T2DM) is a well-established risk factor for cardiovascular disease (CVD). In recent years, self-care has become a central component of diabetes management, with growing emphasis on medication adherence, physical activity, and lifestyle modifications to reduce CVD risk and improve long-term outcomes. As a result, limited capacity for self-care has been increasingly recognized as a major contributor to health disparities.
Approximately 25% of individuals with disabilities have T2DM, and those with physical or mental impairments often face substantial barriers to effective self-management. These challenges-including limited mobility and reduced access to health information-can lead to poor glycemic control and heightened cardiovascular risk.
However, most prior studies have primarily focused on describing the elevated risk of CVD in individuals with disabilities. Whether suboptimal medication adherence mediates the association between disability and cardiovascular outcomes remains unclear.
Therefore, this study aims to compare medication adherence between patients with and without disabilities and to assess whether differences in adherence contribute to disparities in the incidence of CVD.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who newly diagnosed T2DM between between January 1, 2010, and December 31, 2023
排除标准
- •individuals with a history of MI, stroke, percutaneous coronary intervention, peripheral arterial disease, chronic kidney disease, or cancer before the diagnosis of diabetes were excluded.
- •individuals with who already had diabetics related complication
结局指标
主要结局
Major adverse cardiac and cerebrovascular events (MACCE)
时间窗: 10 years after diagnosed T2DM
Composite of MI, ischemic stroke, hemorrhagic stroke, and all-cause mortality
次要结局
- Diabetic neuropathy(10 years after diagnosed T2DM)
- Diabetic foot with amputation(10 years after diagnosed T2DM)
- Proliferative diabetic retinopathy(10 years after diagnosed T2DM)
- Non-proliferative diabetic retinopathy(10 years after diagnosed T2DM)
- Diabetic foot without amputation(10 years after diagnosed T2DM)
研究者
Ki Hong Choi
Professor
Samsung Medical Center