ACTRN12624000716561尚未招募2 期
Spatial mapping of Dupilumab-induced molecular changes in nasal polyp eosinophilia and type 2 inflammation: towards optimised treatment
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 入组人数
- 25
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Adult patients with nasal polyp eosinophilia whose condition is not fully managed by current standard of care
- •Not currently receiving Mepolizumab, Dupilumab or Benralizumab treatment
- •Patients who do not meet the PBS criteria for severe lower airway disease
- •Body weight: A minimum body weight >=40 kilograms (kg) at Visit 1
- •Gender: Male or female.
- •Informed consent: Capable of giving signed written informed consent and willingness to participate to and comply with the study
- •Age over 18 Years
排除标准
- •Subjects with known hypersensitivity to mepolizumab and/or dupilumab
- •Subjects with other conditions that could lead to elevated eosinophils such as Hypereosinophilic Syndromes, including Churg-Strauss Syndrome, or Eosinophilic Esophagitis.
- •Subjects with known immunodeficiency
- •Subjects with cystic fibrosis
- •Pregnant subjects or subjects currently lactating as the effect on human pregnancy is unknown.
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