The Multicenter, Prospective, Real-world Registry of Acute Ischemic Stroke With Large- or Medium-vessel Occlusion
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50,000
- 试验地点
- 1
- 主要终点
- modified Rankin Scale (mRS) score
研究概览
简要总结
This study is designed to observe the treatment options in real-world clinical practice as well as the safety and efficacy of different treatment strategies.
详细描述
LOMEVO is a prospective, multicenter, real-world registry lasting for 10 years. A total of 50000 patients with large- or medium-vessel occlusion will be enrolled at approximately 30 centers around China.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The clinical diagnosis is acute ischemic stroke with large- or medium- vessel occlusion (the criteria followed the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018)
- •Informed consent from the patient or surrogate
排除标准
- •No additional exclusion criteria
结局指标
主要结局
modified Rankin Scale (mRS) score
时间窗: 90±7 days
Ordinal distribution of mRS at 90±7 days; modified Rankin scale (range, 0 to 6, with a score of 0 indicating no disability, 1 no clinically significant disability, 2 slight disability, 3 moderate disability but remaining able to walk unassisted, 4 moderately severe disability, 5 severe disability, and 6 death)
次要结局
- mRS 0-3(90±7 days)
- Excellent functional outcome(90±7 days)
- Change of National Institutes of Health Stroke Scale (NIHSS)(7 days)
- Door-to-Puncture Time (DPT)(24 hours)
- Good functional outcome(90±7 days)
- Onset-to-recanalization time(24 hours)
- Symptom-to-thrombolysis time (STT)(24 hours)
- Door-to-Needle Time (DNT)(24 hours)
- Door-to-Recanalization Time (DRT)(24 hours)
- Puncture-to-recanalization time(24 hours)
研究者
Junwei Hao, MD
Director of Neurology Department
Xuanwu Hospital, Beijing