Chemotherapy Combined With Propranolol Hydrochloride as Neoadjuvant Therapy for Advanced High-grade Serous Ovarian Cancer: A Prospective, Multicenter, Phase II Clinical Study
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 136
- 试验地点
- 1
- 主要终点
- CRS
研究概览
简要总结
Ovarian Cancer (OC) is one of the most common gynecological malignant tumors. In recent years, the incidence of ovarian cancer in China has been on the rise, but its mortality ranks the first among gynecological tumors. Cytoreductive Surgery (CRS) combined with chemotherapy is the standard treatment for patients with advanced ovarian cancer. However, most of the ovarian cancer is stage Ⅲ and above, and there may be a certain degree of organ metastasis. Preclinical studies have found that the stress of melanoma block beta adrenergic signals in mice, which USES beta blockers, checkpoint will enhance resistance to PD - 1 the activity of the inhibitor, to improve the treatment of mice on the immune response. Non-selective β-blockers can also improve the efficacy of melanoma immunotherapy. Retrospective studies have shown that incidental use of β-blockers in combination with antiangiogenic agents, chemotherapy, and immune therapy can prolong DFS, PFS, and OS in cancer patients. A large, multicenter retrospective study found that ovarian cancer patients who took nonselective β-blockers for hypertension had better survival than those who did not. In conclusion, this study aims to explore new auxiliary chemotherapy combined propranolol treatment of high efficacy and safety of ovarian cancer, provide more evidence-based basis for clinic.
详细描述
The study included patients with inoperable stage III or IV ovarian cancer who were initially treated in FIGO stage III or IV. "A phase II trial to explore the efficacy and safety of neoadjuvant chemotherapy plus propranolol in patients with histologically confirmed high-grade serous ovarian cancer." Na row standard subjects were divided into 2 groups: Queue A accept propranolol hydrochloride (20 mg, twice daily), paclitaxel liposomes (135-175 mg/m² on day 1, every 3 weeks), and carboplatin (AUC = 4-5, on day 1, every 3 weeks) were administered as neoadjuvant therapy for a total of 3 cycles, followed by intermittent debulking surgery (IDS). Propranolol hydrochloride was initiated upon definitive pathology and continued until day 14 of the third cycle, with subsequent dose reductions: first by 50% for at least 3 days, then by another 25% for at least 3 days, before complete discontinuation. Queue B receive paclitaxel liposome (135-175 mg/m2, d1, Q3W) and carboplatin (AUC = 4-5, d1, Q3W), neoadjuvant therapy cycle, a total of 3 line then intermittent tumor cells to destroy the loss (interval debulking surgery, IDS); Patients will accept the tumor assessment before the surgery, postoperative by researchers according to aid in the treatment of ovarian cancer guidelines take corresponding.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Written informed consent was obtained before any trial-related procedures were performed.
- •Women, 18 to 75 years old;
- •FIGO stage for stage III or IV, including not surgery in patients with stage III or IV beginning for ovarian cancer; Histopathology confirmed high-grade serous ovarian cancer.
- •According to the response evaluation criteria in 1.1 (RECIST1.1) definition, patients must have a measurable lesions
- •Agreed to provide the participants formalin fixed and tumor tissue specimens or fresh biopsy tissue tumor lesions markers detection
- •ECOG score 0-1 points
- •Expected survival time 6 months or more
- •Enough organ function, without severe hematopoietic dysfunction and heart, lung, liver, kidney dysfunction, and immune deficiency, participants need to satisfy the following laboratory indicators
- •hemoglobin (HGB) 90 g/L or higher
- •Neutrophils (NEUT) acuity 1.5 x 109 / L or white blood cell count (WBC) or 3 x 109 / L
- •Platelet (PLT) or 90 x 109 / L
- •Nmda aminotransferase (AST) 2.5 x ULN or less
- •Alanine aminotransferase (ALT) 2.5 x ULN or less
- •Total bilirubin (TBIL) 1.5 x ULN or less
- •Serum creatinine (SCr) 1.0 x ULN or less
- •Potential fertility women in the group of 7 days before the serum or urine HCG were negative (postmenopausal women considered must be at least 12 months of amenorrhea fertility; Pregnancy tests are not required for women with documented tubal ligation)
- •Potential fertility women are willing to take in the experiment of the medical contraception
排除标准
- •Malignant diseases other than ovarian cancer (excluding radical skin basal cell carcinoma, skin squamous cell carcinoma, and/or radical resection in situ carcinoma) diagnosed within 5 years before the first dose
- •Current are participating in clinical research and treatment of intrusive, or within 4 weeks before the first dose received study used drugs or other treatments
- •Always received pelvic radiotherapy and systemic chemotherapy for ovarian cancer, tumor targeting therapy, immune therapy
- •Need treatment of symptomatic or non-control brain metastasis at the same time, including but not limited to, surgery, radiation and/or corticosteroids, or with the clinical manifestations of spinal cord compression
- •Current use of oral or intravenous beta blockers (atenolol, peso parlour, carvedilol and labetalol, metoprolol, than the parlour, his law such as beta blockers) cannot safely use of propranolol
- •Patients who have previously used propranolol, particularly those who were still on continuous use or had discontinued the medication for less than 14 days within 14 days prior to enrollment, are ineligible for inclusion. Those who have discontinued the medication for ≥14 days and meet the safety criteria as determined by the investigator may be selected for enrollment.
- •Patients with contraindications to β-blockers were excluded according to the contraindications in the propranolol package insert.
- •Patients were receiving systemic glucocorticoids (excluding topical glucocorticoids by nasal spray, inhalation, or other route) or any other form of immunosuppressive therapy within 7 days before the first study dose; Note: allows the use of physiological doses of corticosteroids (10 mg/day or less prednisone or equivalent drugs)
- •Known allogeneic organ transplantation (except corneal transplantation) or allogeneic hematopoietic stem cell transplantation
- •Patients who were allergic to the active ingredient or excipients of propranolol hydrochloride in this study
- •Have not fully recovered from any intervention-related toxicity and/or complications before starting treatment (i.e., ≤ grade 1 or baseline, excluding fatigue or alopecia)
- •Known history of human immunodeficiency virus (HIV) infection (i.e., HIV 1/2 antibody positive)
- •Hepatitis b patients with known
- •Activity of HCV infection subjects (HCV antibody positive and HCV - RNA levels higher than the detection limit)
- •For the first time to give medicine before (1 cycle, day 1) vaccinated live vaccine within 30 days
- •Pregnant or lactating women
- •Any serious or uncontrolled systemic disease, such as
- •resting electrocardiogram (ecg) in rhythm, conduction, or have a significant and severe symptoms to appear on the form is hard to control the exceptions, such as complete left bundle branch block, Ⅱ degrees above heart block, ventricular arrhythmia or atrial fibrillation
- •Unstable angina and congestive heart failure, New York heart association (NYHA) classification of grade 2 or more chronic heart failure
- •Within 6 months before the selected treatment had any arterial thrombosis, embolism, or ischemia, such as myocardial infarction, unstable angina, cerebrovascular accident, or transient ischemic attack, etc.
- •First dose exist within 1 year before need to glucocorticoid treatment of infectious pneumonia history, or the current clinical activity interstitial lung disease; Active tuberculosis
- •There need systemic treatment of active or failure to control the infection
- •Clinical activity diverticulitis, abdominal abscess, gastrointestinal obstruction
- •Liver disease such as cirrhosis of the liver, decompensated liver disease, acute or chronic active hepatitis
- •Mental disorders and unable to cooperate with treatment
- •Any medical history or evidence of illness, abnormal treatment or laboratory values, or other conditions that might interfere with the results of the trial or prevent full participation in the study, or any other potential risk that might be considered by the investigator to be inappropriate for enrollment.
研究组 & 干预措施
experimental group
The patients received propranolol hydrochloride (20 mg, twice daily), paclitaxel liposomes (135-175 mg/m² on day 1, every 3 weeks), and carboplatin (AUC = 4-5 on day 1, every 3 weeks) as neoadjuvant therapy for a total of 3 cycles, followed by intermittent debulking surgery (IDS). Propranolol hydrochloride was administered starting after definitive pathology confirmation and continued until day 14 of the third cycle, with subsequent dose reductions: first by 50% for at least 3 days, then by another 25% for at least 3 days, before complete discontinuation.
干预措施: Carboplatin (Drug)
Control group
Adhere to neoadjuvant therapy with paclitaxel liposomes (135-175 mg/m², day 1, every 3 weeks) and carboplatin (AUC = 4-5, day 1, every 3 weeks) for a total of 3 cycles, followed by intermittent debulking surgery (IDS).
干预措施: Paclitaxel liposome (Drug)
experimental group
The patients received propranolol hydrochloride (20 mg, twice daily), paclitaxel liposomes (135-175 mg/m² on day 1, every 3 weeks), and carboplatin (AUC = 4-5 on day 1, every 3 weeks) as neoadjuvant therapy for a total of 3 cycles, followed by intermittent debulking surgery (IDS). Propranolol hydrochloride was administered starting after definitive pathology confirmation and continued until day 14 of the third cycle, with subsequent dose reductions: first by 50% for at least 3 days, then by another 25% for at least 3 days, before complete discontinuation.
干预措施: Paclitaxel liposome (Drug)
Control group
Adhere to neoadjuvant therapy with paclitaxel liposomes (135-175 mg/m², day 1, every 3 weeks) and carboplatin (AUC = 4-5, day 1, every 3 weeks) for a total of 3 cycles, followed by intermittent debulking surgery (IDS).
干预措施: Carboplatin (Drug)
experimental group
The patients received propranolol hydrochloride (20 mg, twice daily), paclitaxel liposomes (135-175 mg/m² on day 1, every 3 weeks), and carboplatin (AUC = 4-5 on day 1, every 3 weeks) as neoadjuvant therapy for a total of 3 cycles, followed by intermittent debulking surgery (IDS). Propranolol hydrochloride was administered starting after definitive pathology confirmation and continued until day 14 of the third cycle, with subsequent dose reductions: first by 50% for at least 3 days, then by another 25% for at least 3 days, before complete discontinuation.
干预措施: Propranolol Hydrochloride (Drug)
结局指标
主要结局
CRS
时间窗: 3-month
Chemotherapy Response Scoring：Pathological assessment was conducted on the retinal tissue removed during the surgery
次要结局
- R0 resection rate(3-month)
- Overall Response Rate (ORR) After Neoadjuvant treatment(3-month)
- Pathological complete remission rate(3-month)
- 12-month disease-free survival rate(12 months)
- 12-month survival rate(12 months)
研究者
Bai-Rong Xia
Chairman of Department of Gynaecology Surgery
Anhui Provincial Cancer Hospital