Comparison of chemotherapy combined with percutaneous electroporation and chemotherapy alone in the management of locally advanced carcinoma of the gall bladder

Gall bladder carcinoma (GBC) is the most common malignancyof the biliary tract worldwide. However, most of the patients often presentlate. Therefore, surgical resection may not be possible due to adjacent organinvolvement or local invasion. Chemotherapy is the first line of treatment inunresectable GB masses with dismissal prognosis. In electrochemotherapy (ECT),the short-term electric pulses with high voltage delivered to the tumor, leadsto transient pore formation in the cell membrane which enables the entry ofchemotherapeutic agents into the cells. The hypothesis of this study is thatthe chemotherapy with electroporation may improve the outcome of GBC. This is arandomized control trial of 30 patients with locally advanced GBC who will bedesignated randomly into two equal groups. Group I will receive only chemotherapywhile Group II will receive both chemotherapy and percutaneous electroporation.The primary outcome will be overall survival and the secondary outcome will besafety and quality of life after the procedure.