Clinical and Hematologic Risk Factors of Right Ventricular Dysfunction and Pulmonary Hypertension in Myeloproliferative Neoplasms
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 145
- 主要终点
- Prevalence of Pulmonary Hypertension in MPN Patients
研究概览
简要总结
This cross-sectional study aims to determine the prevalence of pulmonary hypertension and right ventricular dysfunction in patients with myeloproliferative neoplasms and to identify associated clinical and hematologic factors.
详细描述
Myeloproliferative neoplasms (MPNs) are associated with an increased risk of pulmonary hypertension and right ventricular dysfunction. This observational study will include adults with confirmed polycythemia vera, essential thrombocythemia, or primary myelofibrosis.
All participants will undergo clinical assessment, laboratory evaluation, and echocardiography to assess pulmonary artery systolic pressure and right ventricular systolic function (TAPSE, FAC, and tissue Doppler S').
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Age 18 years or older
- •Confirmed diagnosis of myeloproliferative neoplasm (polycythemia vera, essential thrombocythemia, or primary myelofibrosis)
- •Stable clinical condition
- •Written informed consent
排除标准
- •- Significant left-sided valvular heart disease
- •Congenital heart disease
- •COPD or interstitial lung disease causing pulmonary hypertension
- •Poor echocardiographic window
研究组 & 干预措施
Single cohort: Patients with myeloproliferative neoplasms
Adult patients with myeloproliferative neoplasms who will undergo clinical, laboratory, and echocardiographic assessment for pulmonary hypertension and right ventricular dysfunction.
结局指标
主要结局
Prevalence of Pulmonary Hypertension in MPN Patients
时间窗: Baseline
PASP measured by echocardiography using TR velocity. Pulmonary hypertension defined as PASP greater than 35 mmHg or TR velocity greater than 2.8 m/s. Prevalence will be calculated.
次要结局
- Prevalence of right ventricular dysfunction(Baseline)
- Pulmonary artery systolic pressure(Baseline)
- Tricuspid annular plane systolic excursion (TAPSE)(Baseline)
- Right ventricular fractional area change(Baseline)
研究者
Esraa medhat Ahmed
Resident Physician
Assiut University