ACTRN12623000862640尚未招募Unknown
Assessment of the feasibility, safety, tolerability and efficacy of dulaglutide, a glucagon-like peptide-1 receptor agonist in dialysis patients
适应症
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 入组人数
- 95
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •1.Type 2 diabetes.
- •2.Stable on either haemodialysis, peritoneal dialysis or hybrid therapy (both haemodialysis and peritoneal dialysis) for at least 3 months.
- •3.Aged 18 years old or older
- •4.Able to give informed consent.
- •5.HbA1c >53mmol/mol
排除标准
- •Exclusion criteria
- •1.Known allergy or adverse drug effect to GLP-1 receptor agonists
- •2.Known severe hepatic dysfunction such as portal hypertension or cirrhosis, acute or chronic hepatitis, signs or symptoms of other liver disease, or an alanine transaminase (ALT) level >3 times the upper limit of normal
- •3.Have a past history of acute, chronic or idiopathic pancreatitis
- •4.Excessive alcohol intake above recommended levels
- •5.Type 1 diabetes
- •6.Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia 2A or 2B
- •7.Malnutrition
- •8.Pregnancy
- •9.Planning for coronary, carotid or peripheral artery revascularisation
- •10.Known clinically significant gastric emptying abnormality (for example, severe diabetic gastroparesis or gastric outlet obstruction) or had undergone gastric bypass (bariatric) surgery
- •11.Acute coronary syndrome or cerebrovascular event within 14 days prior to screening
- •12.In the judgement of the investigator, have any other condition that is likely to limit protocol compliance or reporting of adverse events
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