A Real-world Study on the Long-term Prognosis of Acute-on-chronic Liver Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- mortality rate of bacterial or fungal infection
研究概览
简要总结
The subjects of this study were inpatients with ACLF who were admitted to Tongji Hospital in Wuhan from March 2023 to June 2025. After patients were enrolled, The patient's general information (gender, age, past medical history, etc.), complications (ascites, hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding, etc.), laboratory tests (CRP, PCT, INR, WBC, fungal/bacterial diagnostic tests, etc.), symptoms and signs at the time of infection, and at admission (D1), D4, D7, D14, D21, etc.) were recorded Save the blood separately. The patients were divided into fungal infection group, bacterial infection group and non-infection group according to the infection status after admission.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •TBIL ≥ 12 mg/mL and INR ≥ 1.5
- •Chronic hepatitis B
排除标准
- •(1) <18 or >80 years old; (2) primary hepatic or extrahepatic carcinoma; (3) with severe diseases of other organs or systems; (4) pregnancy; (5) imcomplete information
结局指标
主要结局
mortality rate of bacterial or fungal infection
时间窗: 28 days and 90 days
mortality rate of bacterial or fungal infection
incidence rate of bacterial or fungal infection
时间窗: 28 days and 90 days
incidence rate of bacterial or fungal infection
次要结局
- incidence rate of complications(28 days and 90 days)
研究者
Qin Ning
Professor
Tongji Hospital