Response of the Cardiac Autonomic Control System After Oxygen Therapy 100% in Hyperbaric Environment
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Heart Rate Variability- Time messurment
研究概览
简要总结
The purpose of this study is to examine changes in cardiac autonomic nerve system function in patients receiving Hyperbaric oxygen therapy .
详细描述
Effects of hyperbaric environment treatment Hyperbaric oxygen therapy (A pressure chamber) is used to treat various conditions in which there is tissue ischemia (a hard wound healing, radiation damage) and in situations where there are air bubbles that should be reduced (decompression - diving accidents, air embolism). Studies from recent years show that hyperbaric oxygen therapy can stimulate brain neuropathy in patients after a stroke and head trauma. Clinically, the evaluation to date includes motor tests and cognitive tests.
The hyperbolic influence on the cardiac autonomic nerve system in healthy subjects is reflected in an increase in activity in the parasympathetic subsystem. The effect of hyperbaric oxygen therapy (100% increase in environmental pressure with oxygen) on autonomic system activity has not yet been tested in patients receiving a series of pressure cell treatments.
The purpose of this study is to examine changes in autonomic system function in patients receiving Hyperbaric oxygen therapy .
After signing the Informed Consent Form, they will be asked to be examined at four time periods: about two weeks before starting treatment, six weeks after starting treatment, last week for the treatment series (if the treatment continues for more than 6 weeks / 30 weeks) and about one month after treatment ends.
Each time the subject is connected to a Polar clock and a breathing strip. An hour-long test will be conducted during which the subjects will be asked to perform:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who are scheduled to receive a series of treatments at a pressure cell at Assaf Harofeh Hospital and are willing to participate in the study.
排除标准
- •Patients who received previous hyperbaric oxygen therapy for any reason during the 6 months prior to inclusion.
- •A history of malignancy during the last year of inclusion.
- •A pulmonary disease that does not allow the patient to be admitted to a pressure cell (severe emphysema, moderate obstruction) .
- •patients that unable to sign informed consent form.
结局指标
主要结局
Heart Rate Variability- Time messurment
时间窗: 3 month
the square Root of the Mean Square successive RR differences(RMSSD) , Mean RR- Mean of R-R intervals.
次要结局
未报告次要终点