Can Food Timing Reduce Your Diabetes Risk?
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Difference in diet-induced thermogenesis between Meal Conditions and Shift Work
研究概览
简要总结
The goal of this clinical trial is to test whether food timing impacts metabolic health in healthy participants.
Participants will:
- complete 2 inpatient stays
- be provided with test meals
- have frequent blood draws
详细描述
The investigators aim to investigate the influence of different food timing, without changing 24-h caloric and nutrient intake, on glucose and fat tolerance and energy expenditure in healthy people on a simulated day or night shift.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy with no acute or chronic medical and psychiatric disorders
- •BMI: 18.5-29.9 kg/m2
排除标准
- •Smokers, current tobacco or e-cigarette use
- •Drug or alcohol dependency
结局指标
主要结局
Difference in diet-induced thermogenesis between Meal Conditions and Shift Work
时间窗: 24 hours
Postprandial energy expenditure incremental area under the curve (AUC) from mixed meal tests
Difference in plasma triglyceride level between Meal Conditions and Shift Work
时间窗: 24 hours
Triglyceride area under the curve (AUC) over 24 hours
Difference in glucose tolerance between Meal Conditions and Shift Work
时间窗: 24 hours
Glucose incremental area under the curve (AUC) from mixed meal tests
次要结局
- Difference in postprandial incretin level between Meal Conditions and Shift Work(24 hours)
- Difference in insulin sensitivity between Meal Conditions and Shift Work(24 hours)
- Difference in beta-cell function between Meal Conditions and Shift Work(24 hours)
- Difference in 24-h glycemia between Meal Conditions and Shift Work(24 hours)
- Difference in plasma free fatty acids level between Meal Conditions and Shift Work(24 hours)
- Difference in substrate oxidation between Meal Conditions and Shift Work(24 hours)
研究者
Frank AJL Scheer, PhD
Professor
Brigham and Women's Hospital