Comparison of Blood Flow in the Arteriae Uterinae in Ovarian Stimulation Cycles for IVF/ICSI, in Hormonal Replacement Cycles and Natural Cycles for Frozen Embryo Transfer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 124
- 试验地点
- 1
- 主要终点
- Difference in the blood flow, calculated as Pulsatility Index (PI) and Resistance Index (RI), between the HRT- and the NC-FET cycles
研究概览
简要总结
This study will measure the blood flow in the aa. uterinae in women, undergoing firstly ovarian stimulation for In-Vitro Fertilization (IVF) / Intracytoplasmic sperm injection (ICSI), in Hormonal Replacement cycles (HRT) and Natural cycles (NC) for Frozen Embryo Transfer (FET)
详细描述
To evaluate the influence of ovarian stimulation on the blood flow in the arteriae uterinae as well as whether there is an influence of the type of endometrial preparation for FET with either hormonal replacement therapy or natural cycle on the blood flow of the arteria uterina left / right
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients who undergo ovarian stimulation in a Gonadotropin-Releasing-Hormone (GnRH)-antagonist protocol for IVF / ICSI
- •Patients who have vitrified embryo(s)
- •Preparation for FET either in HRT or NC cycle
排除标准
- •Poor responder according to Bologna criteria (Ferraretti et al.) as follows:
- •At least two of the following three features must be present:
- •(i) Advanced maternal age (≥40 years) or any other risk factor for poor ovarian reserve (POR);
- •(ii) A previous POR (≤3 oocytes with a conventional stimulation protocol);
- •(iii) An abnormal ovarian reserve test (i.e. antral follicle count (AFC) 5-7 follicles or anti-mullerian hormone (AMH) 0.5 -1.1 ng/ml).
- •Uterine surgery for removal of fibroids (hysteroscopic, laparoscopic) or removal of uterine septum
- •Endometriosis
- •Asherman-Syndrome
- •Previous cytotoxic treatment
- •Previous radiation of the uterus / adnexal region
- •Known hypertension
- •Intake of Aspirin or similar medication which might influence the blood flow
- •Status after tubal ligation
- •Status after surgery in the adnexal region on 1 side
结局指标
主要结局
Difference in the blood flow, calculated as Pulsatility Index (PI) and Resistance Index (RI), between the HRT- and the NC-FET cycles
时间窗: 1 day
On the day of progesterone administration / progesterone rise. Quantitative continuous variable
次要结局
- Number of days of estradiol exposure(1 day)
- Continuous quantitative variable measured as the differences between average RI value(2 days)
- Thickness of the lining(1 day)
- Continuous quantitative variable measured as the differences between average PI value(1 day)
研究者
Barbara Lawrenz
Scientific Director
ART Fertility Clinics LLC