An Open Label Study to Investigate the Role of Ivacaftor (VX-770) for the Treatment of Chronic Bronchitis With CFTR Dysfunction
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- change in lung function
研究概览
简要总结
This research study will test how well a new drug affects bronchiectasis or chronic bronchitis. The new drug, Ivacaftor (KALYDECO), is a drug that has recently been approved by the U.S. Food and Drug Administration (FDA) for patients with a lung disease called Cystic Fibrosis (CF). It has not been approved for use in patients with bronchiectasis or chronic bronchitis.
详细描述
The study is an open label study of orally-administered ivacaftor in subjects with chronic bronchitis and/or bronchiectasis. Subjects will be administered the study drug ivacaftor 150 mg twice daily (BID). The study drug is commercially available and will be purchased by the participant.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or Female age 18 years
- •A Clinical diagnosis of Bronchiectasis and/or Chronic Bronchitis in the investigators opinion
- •Exhibit symptoms of chronic bronchitis as defined by the Medical Research Council
- •FEV1 percent predicted greater than 40 percent Post Bronchodilator
- •Clinically stable in the last 4 weeks with no evidence of exacerbation
- •Weight of 40 kg to120 kg
- •Willingness to use at least one form of acceptable birth control including abstinence, condom with spermicide, or hormonal contraceptives
- •Willing to monitor blood glucose if known history of diabetes mellitus requiring insulin or medical therapy
- •Element of CFTR Dysfunction, as defined by Sweat Chloride
- •Daytime use of Oxygen Therapy
- •Documented history of drug abuse within the last year
- •Subjects should not have a pulmonary exacerbation or changes in therapy for pulmonary disease within 28 days before receiving the first dose of study drug.
- •Cirrhosis or elevated liver transaminases > 3X ULN
- •GFR < 50 estimated by Cockroft-Gault
- •Any illness or abnormal lab finding that, in the opinion of the investigator might confound the results of the study or pose an additional risk in administering study drug to the subject.
- •Pregnant or Breastfeeding
- •Subjects taking any inhibitors or inducers of CYP3A4, including certain herbal medications and grapefruit juice. (Excluded medications and foods including the drugs and foods are provided in the appendix document)
- •Uncontrolled Diabetes
- •Clinically significant arrhythmias or conduction abnormalities that in the opinion of the investigator that affect patient safety
排除标准
- 未提供
研究组 & 干预措施
Ivacaftor (VX770)
Ivacaftor (VX-770) for the Treatment of Chronic Bronchitis with CFTR Dysfunction
干预措施: Ivacaftor (VX-770) (Drug)
结局指标
主要结局
change in lung function
时间窗: 1 year
次要结局
未报告次要终点
研究者
George Solomon
Principal Investigator
University of Alabama at Birmingham